Department of Biochemistry, University of Lausanne, Switzerland.
Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.BAI-0003-2019.
Inflammasomes are multiprotein signaling complexes that are assembled by cytosolic sensors upon the detection of infectious or noxious stimuli. These complexes activate inflammatory caspases to induce host cell death and cytokine secretion and are an essential part of antimicrobial host defense. In this review, I discuss how intracellular bacteria are detected by inflammasomes, how the specific sensing mechanism of each inflammasome receptor restricts the ability of bacteria to evade immune recognition, and how host cell death is used to control bacterial replication .
炎症小体是一种多蛋白信号复合物，当细胞内传感器检测到感染或有害刺激时，炎症小体就会被组装起来。这些复合物激活炎症性半胱天冬酶，诱导宿主细胞死亡和细胞因子分泌，是抗菌宿主防御的重要组成部分。在这篇综述中，我讨论了炎症小体如何检测细胞内细菌，每个炎症小体受体的特定传感机制如何限制细菌逃避免疫识别的能力，以及如何利用宿主细胞死亡来控制细菌复制。
