U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Via G. Moscati 31, 00168, Roma, Italy.
Università Cattolica del Sacro Cuore, Roma, Italy.
Urolithiasis. 2019 Jun;47(3):219-224. doi: 10.1007/s00240-019-01119-z. Epub 2019 Mar 8.
Currently an evidence-based approach to nephrolithiasis is hampered by a lack of randomized controlled trials. Thus, there is a need for common platforms for data sharing and recruitment of patients to interventional studies. A first step in achieving this objective would be to share practice methods and protocols for subsequent standardization in what is still a heterogeneous clinical field. Here, we present the results of a pilot survey performed across 24 European clinical kidney stone centers. The survey was distributed by a voluntary online questionnaire circulated between June 2017 and January 2018. About 46% of centers reported seeing on average 20 or more patients per month. Only 21% adopted any formal referral criteria. Centers were relatively heterogeneous in respect of the definition of an incident stone event. The majority (71%) adopted a formal follow-up scheme; of these, 65% included a follow-up visit at 3 and 12 months, and 41% more than 12 months. In 79% of centers some kind of imaging was performed systematically. 75% of all centers performed laboratory analyses on blood samples at baseline and during follow-up. All centers performed laboratory analyses on 24-h urine samples, the majority (96%) at baseline and during follow-up. There was good correspondence across centers for analyses performed on 24-h urine samples, although the methods of 24-h urine collection and analysis were relatively heterogeneous. Our survey among 24 European stone centers highlights areas of homogeneity and heterogeneity that will be investigated further. Our aim is the creation of a European network of stone centers sharing practice patterns and hosting a common database for research and guidance in clinical care.
目前,由于缺乏随机对照试验,基于证据的肾结石治疗方法受到了阻碍。因此,需要有共同的数据共享平台和患者招募渠道,以开展干预性研究。实现这一目标的第一步是分享实践方法和方案,以便在这个仍然存在很大异质性的临床领域实现标准化。在这里,我们展示了在 24 个欧洲临床肾结石中心进行的试点调查结果。该调查通过自愿在线问卷在 2017 年 6 月至 2018 年 1 月期间进行分发。大约 46%的中心报告称平均每月看诊 20 名或以上患者。只有 21%的中心采用了任何正式的转诊标准。各中心在结石事件的定义方面存在较大差异。大多数中心(71%)采用了正式的随访方案;其中,65%的中心包括 3 个月和 12 个月的随访,41%的中心随访时间超过 12 个月。71%的中心进行某种形式的影像学检查。75%的中心在基线和随访期间对血液样本进行实验室分析。所有中心都对 24 小时尿液样本进行实验室分析,其中大多数中心(96%)在基线和随访期间进行分析。各中心在对 24 小时尿液样本的分析方面具有较好的一致性,尽管 24 小时尿液采集和分析的方法存在较大差异。我们对 24 个欧洲结石中心的调查突出了同质性和异质性的领域,这些领域将进一步进行研究。我们的目标是建立一个共享实践模式的欧洲结石中心网络,并为研究和临床护理指南建立一个共同的数据库。