Involvement of PFKFB3 in Pulmonary Arterial Hypertension Pathogenesis. Is It All about Glycolysis?
作者信息
Bonnet Sebastien, Paulin Roxane
机构信息
Institut Universitaire de Cardiologie et de Pneumologie de QuébecUniversité LavalQuebec City, Quebec, Canada.
出版信息
Am J Respir Crit Care Med. 2019 Sep 1;200(5):532-534. doi: 10.1164/rccm.201902-0394ED.
Abstract
摘要
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Involvement of PFKFB3 in Pulmonary Arterial Hypertension Pathogenesis. Is It All about Glycolysis?PFKFB3参与肺动脉高压发病机制。这一切都与糖酵解有关吗？
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本文引用的文献
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PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.PFKFB3 在平滑肌中促进肺动脉高压中的血管重塑。
Am J Respir Crit Care Med. 2019 Sep 1;200(5):617-627. doi: 10.1164/rccm.201812-2290OC.
2
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis.乙酰化作用将 PFKFB3 积累在细胞质中，以促进糖酵解，并保护细胞免受顺铂诱导的细胞凋亡。
Nat Commun. 2018 Feb 6;9(1):508. doi: 10.1038/s41467-018-02950-5.
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Roles of PFKFB3 in cancer.PFKFB3 在癌症中的作用。
Signal Transduct Target Ther. 2017 Nov 24;2:17044. doi: 10.1038/sigtrans.2017.44. eCollection 2017.
4
The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer.将磷酸果糖激酶-2/果糖-2,6-二磷酸酶3（PFKFB3）作为抗癌治疗策略的分子基础。
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The metabolic theory of pulmonary arterial hypertension.肺动脉高压的代谢理论。
Circ Res. 2014 Jun 20;115(1):148-64. doi: 10.1161/CIRCRESAHA.115.301130.
6
Endothelial PFKFB3 plays a critical role in angiogenesis.内皮细胞 PFKFB3 在血管生成中起着关键作用。
Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1231-9. doi: 10.1161/ATVBAHA.113.303041. Epub 2014 Apr 3.
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Circulation. 2014 Feb 18;129(7):786-97. doi: 10.1161/CIRCULATIONAHA.113.006167. Epub 2013 Nov 22.
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