Burden H W, Leonard M J, Hodson C A, Louis T M, Lawrence I E
Neuroendocrinology. 1986;42(6):449-55. doi: 10.1159/000124486.
The effects of abdominal vagotomy at proestrus on ovarian weight and antral follicles greater than 150 microns diameter and on serum levels of gonadotropins and testosterone were assessed 24 and 48 h and 4 and 8 days after surgery. Serum levels of estradiol were assessed at 4 and 8 days. Vagotomy increased ovarian weight at 48 h, decreased ovarian weight at 4 days, but had no effect by day 8. Vagotomy increased healthy antral follicles 151-394 microns diameter at 24 and 48 h and increased atresia in this size range at 4 and 8 days. Vagotomy decreased healthy follicles 151-384 microns at day 8. Vagotomy decreased healthy follicles 395-570 microns at 24 h and decreased atretic follicles at 48 h. Vagotomy decreased the largest (over 570 micron diameter) healthy follicles at 24 h and 8 days. Vagotomy decreased basal serum LH levels at 48 h and 8 days. (In contrast, vagotomy increased FSH at 24 h). There was no effect on blood levels of estradiol and testosterone. These findings are discussed in relation to the hypothesis that the vagus nerve is a component of the hypothalamo-hypophyseal-ovarian axis.
在动情前期进行腹部迷走神经切断术，于术后24小时、48小时、4天和8天评估其对卵巢重量、直径大于150微米的窦状卵泡以及促性腺激素和睾酮血清水平的影响。在4天和8天评估雌二醇的血清水平。迷走神经切断术在48小时时增加卵巢重量，在4天时降低卵巢重量，但在第8天时无影响。迷走神经切断术在24小时和48小时时增加直径为151 - 394微米的健康窦状卵泡数量，并在4天和8天时增加该尺寸范围内的卵泡闭锁。在第8天时，迷走神经切断术减少直径为151 - 384微米的健康卵泡数量。在24小时时，迷走神经切断术减少直径为395 - 570微米的健康卵泡数量，并在48小时时减少闭锁卵泡数量。在24小时和8天时，迷走神经切断术减少最大的（直径超过570微米）健康卵泡数量。迷走神经切断术在48小时和8天时降低基础血清促黄体生成素水平。（相比之下，迷走神经切断术在24小时时增加促卵泡生成素水平）。对雌二醇和睾酮的血液水平无影响。结合迷走神经是下丘脑 - 垂体 - 卵巢轴组成部分这一假说对这些发现进行了讨论。
