Strubbe J H, Keyser J, Dijkstra T, Prins A J
Physiol Behav. 1986;36(3):489-93. doi: 10.1016/0031-9384(86)90320-3.
Feeding at the beginning of the night is probably dependent on the rat's immediate energy requirements while feeding at the end may have an anticipatory function. This latter feeding peak may be mainly controlled by a circadian pacemaker. The aim of this study was to investigate the relative contribution of satiety signals and circadian pacemakers in the control of feeding behavior. Food intake was monitored after infusion of liquid food into the stomach during several parts of the day-night cycle to prevent a possible influence of oral sensations. It is demonstrated that intragastric infusion is more effective in suppressing intake during daytime and the first half of the dark phase than during the second half of the dark phase. Suppressions of food intake are mainly due to delaying the first occurrence of food ingestion, whereas the size of that meal is less affected. During the last period of the night no significant delay could be brought about. These experiments suggest that in the rat a circadian pacemaker dominates feeding motivation during the end of the night thereby strongly interacting with caloric control of feeding behavior.
夜间开始时的进食可能取决于大鼠即时的能量需求，而夜间结束时的进食可能具有前瞻性作用。后一个进食高峰可能主要受昼夜节律起搏器控制。本研究的目的是调查饱腹感信号和昼夜节律起搏器在控制进食行为中的相对作用。在昼夜周期的几个时间段向胃内注入流食后监测食物摄入量，以防止口腔感觉可能产生的影响。结果表明，胃内注入流食在白天和黑暗期前半段比黑暗期后半段更有效地抑制食物摄入。食物摄入的抑制主要是由于延迟了首次进食的时间，而每餐的食量受影响较小。在夜间最后阶段，无法产生显著延迟。这些实验表明，在大鼠中，昼夜节律起搏器在夜间结束时主导进食动机，从而与进食行为的热量控制强烈相互作用。
