抗氧化能力较弱的触珠蛋白表型会增加加纳接受高效抗逆转录病毒治疗的 HIV 感染患者的心血管疾病风险因素。

Haptoglobin phenotypes with weak antioxidant capacity increase risk factors of cardiovascular disease in Ghanaian HIV-infected patients on highly active antiretroviral therapy.

机构信息

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra, Ghana.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Science, University of Ghana, Korle Bu, Accra, Ghana.

出版信息

Trop Med Int Health. 2019 Jun;24(6):766-774. doi: 10.1111/tmi.13229. Epub 2019 Mar 21.

DOI:10.1111/tmi.13229

PMID:30851231

Abstract

OBJECTIVE

Highly active antiretroviral therapy (HAART) has considerably reduced HIV/AIDS-related morbidity and mortality; however, the therapy has been associated with the development of cardiovascular disease (CVD), and genetic predisposition factors may aggravate disease outcome. This study was aimed at investigating the relationship between haptoglobin phenotypes and risk factors of CVD in HIV patients.

METHODS

A total of 105 HIV sero-positive patients on HAART and 75 HIV-infected HAART-naïve individuals were enrolled in the study. Socio-demographics and clinical characteristics of the participants were obtained using a well-structured questionnaire. Lipid profile, lactate dehydrogenase (LDH) and haptoglobin (Hp) phenotypes were analysed from serum whiles haemoglobin (Hb) level, CD4 cell count and HIV viral RNA load were determined using whole blood.

RESULTS

Atherogenic index of plasma (AIP) was significantly higher in patients on HAART than the naïve group (P < 0.05). Age, BMI, visceral fat, systolic blood pressure LDH and lipid variables strongly and positively correlated with AIP (P < 0.05), with the exception of HDL-c (P < 0.001) which showed a negative correlation. HAART was associated with hypertension (χ = 4.33, P = 0.037), hypercholesterolaemia (χ = 10.99, P < 0.001), elevated LDL-c (χ = 10.30, P < 0.001) and decreased HDL-c (χ = 3.87, P = 0.09). Hp2-2 and Hp0 collectively was strongly associated with hypertension (OR = 2.54, P = 0.011), obesity (OR = 5.97, P < 0.001) and hypercholesterolaemia (OR = 2.99, P < 0.001).

CONCLUSION

HIV/AIDS patients on HAART expressing Hp phenotypes with weak antioxidant capacity have an increased risk of developing CVD.

摘要

目的

高效抗逆转录病毒疗法（HAART）显著降低了与 HIV/AIDS 相关的发病率和死亡率；然而，该疗法与心血管疾病（CVD）的发生有关，遗传易感性因素可能会加重疾病的预后。本研究旨在探讨 HIV 患者中结合珠蛋白表型与 CVD 危险因素之间的关系。

方法

本研究共纳入 105 例接受 HAART 的 HIV 血清阳性患者和 75 例接受 HAART 的 HIV 感染未接受治疗的个体。使用结构良好的问卷获得参与者的社会人口统计学和临床特征。分析血清中的血脂谱、乳酸脱氢酶（LDH）和结合珠蛋白（Hp）表型，同时使用全血测定血红蛋白（Hb）水平、CD4 细胞计数和 HIV 病毒 RNA 载量。

结果

接受 HAART 的患者的血浆致动脉粥样硬化指数（AIP）明显高于未接受治疗的组（P<0.05）。年龄、BMI、内脏脂肪、收缩压、LDH 和血脂变量与 AIP 呈强烈正相关（P<0.05），除了高密度脂蛋白胆固醇（HDL-c）（P<0.001）呈负相关。HAART 与高血压（χ ²=4.33，P=0.037）、高胆固醇血症（χ ²=10.99，P<0.001）、升高的 LDL-c（χ = 10.30，P<0.001）和降低的 HDL-c（χ ²=3.87，P=0.09）相关。Hp2-2 和 Hp0 共同与高血压（OR=2.54，P=0.011）、肥胖（OR=5.97，P<0.001）和高胆固醇血症（OR=2.99，P<0.001）强烈相关。