在尼日利亚拉各斯的一家治疗中心，接受高效抗逆转录病毒疗法 (HAART) 治疗的 HIV 血清阳性志愿者中心血管疾病的风险。

Risks of cardio-vascular diseases among highly active antiretroviral therapy (HAART) treated HIV seropositive volunteers at a treatment centre in Lagos, Nigeria.

机构信息

Department of Medical Laboratory Science, College of Medicine, University of Lagos, Idi-araba, Lagos State, Nigeria.

Clinical Diagnostic Laboratory, Nigerian Institute of Medical Research, Yaba, Lagos State, Nigeria.

出版信息

Pan Afr Med J. 2021 Feb 23;38:206. doi: 10.11604/pamj.2021.38.206.26791. eCollection 2021.

DOI:10.11604/pamj.2021.38.206.26791

PMID:33995812

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8106780/

Abstract

INTRODUCTION

highly active antiretroviral therapy (HAART) has led to a decline in HIV-induced morbidity and mortality in recent years. However, it has been opined that this has led to elevated risks of cardiovascular diseases (CVDs). This study assessed the risks of CVDs among HAART experienced individuals living with HIV.

METHODS

a cross sectional study involving 196 adults consisting of 118 HAART experienced and 78 HAART naïve was conducted. Anthropometric and blood pressure measurements were recorded for all participants. Blood samples obtained from the volunteers were used to determine glucose, creatinine, HIV viral load, CD4 count and lipid profile using standard methods. Lipid ratios, atherogenic indices and QRISK3 risk score were calculated.

RESULTS

the median CD4 lymphocyte, mean body mass index (BMI) and HDL-c in HAART experienced participants were higher (P<0.05) than HAART naive individuals. The QRISK3 risk score and creatinine were higher (p<0.05) among HAART experienced group. In HAART experienced group, the risk of hypertension, increased low-density lipoprotein (LDL-c), atherogenic index of plasma (AIP) and QRISK3 were 3.7, 2.0, 2.38 and 3.85 times (p<0.05) higher respectively than in HAART naive. Atherogenic coefficient (AC) increase was more prevalent among male (p<0.05) participants. Risk of chronic renal disease (eGFR), hypertension and CVD (as measured by QRISK3) was higher (p<0.05) among the female and older participants respectively.

CONCLUSION

the risk of CVDs and renal disease appeared to be higher among HAART experienced volunteers and older (>45 years) volunteers. The risk of renal disease appeared higher in females.

摘要

简介

高效抗逆转录病毒疗法（HAART）近年来导致了 HIV 引起的发病率和死亡率的下降。然而，有人认为这导致了心血管疾病（CVDs）的风险增加。本研究评估了接受 HAART 的 HIV 感染者发生 CVDs 的风险。

方法

进行了一项横断面研究，纳入了 196 名成年人，包括 118 名接受过 HAART 的人和 78 名未接受过 HAART 的人。对所有参与者进行了人体测量和血压测量。从志愿者身上采集的血液样本用于使用标准方法确定葡萄糖、肌酐、HIV 病毒载量、CD4 计数和血脂谱。计算了脂质比、致动脉粥样硬化指数和 QRISK3 风险评分。

结果

接受过 HAART 的参与者的中位数 CD4 淋巴细胞、平均体重指数（BMI）和高密度脂蛋白胆固醇（HDL-c）较高（P<0.05）。HAART 经验组的 QRISK3 风险评分和肌酐较高（p<0.05）。在接受过 HAART 的组中，高血压、升高的低密度脂蛋白（LDL-c）、血浆致动脉粥样硬化指数（AIP）和 QRISK3 的风险分别高出 3.7、2.0、2.38 和 3.85 倍（p<0.05）。男性参与者中致动脉粥样硬化系数（AC）增加更为普遍（p<0.05）。女性和年龄较大（>45 岁）的参与者发生慢性肾脏病（eGFR）、高血压和 CVD（通过 QRISK3 测量）的风险较高（p<0.05）。