Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan; Polymeric Biomaterials Group, Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan; Nanostructured Semiconducting Materials Group, Nano-Power Field, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Colloids Surf B Biointerfaces. 2019 Jun 1;178:111-119. doi: 10.1016/j.colsurfb.2019.02.053. Epub 2019 Mar 1.
To fabricate a soft-tissue adhesion surface by nanostructural control and functional modification, we prepared bio-inspired adhesive surfaces composed of hexanoyl group-modified gelatin (HxGltn) and silicon nanowire (SiNW). We synthesized the HxGltn with different modification ratios of 27 mol% (27HxGltn), 37 mol% (37HxGltn), and 50 mol% (50HxGltn) and processed two different types of SiNW plates (800 pitch and 1500 pitch) with 1400 nm in height and 400 nm in diameter (800/1400 SiNW and 1500/1400 SiNW, respectively. To enhance the adhesion to the intestine surface, we covalently immobilized HxGltn on the surface of SiNW plates. A significant increase in bonding strength was not observed when Gltn-, 27HxGltn-immobilized 800/1400 SiNW, and Gltn-, 27HxGltn, 37HxGltn, 50HxGltn-immobilized 1500/1400 SiNW were used. Furthermore, 37HxGltn- and 50HxGltn-immobilized 800/1400 SiNW only showed 5-fold higher bonding strength to intestine tissue compared with other samples. These 37HxGltn- and 50HxGltn-immobilized 800/1400 SiNW surfaces had potential for the application of soft tissue adhesion.
为了通过纳米结构控制和功能修饰来制造软组织黏附表面，我们制备了由己酰基修饰明胶（HxGltn）和硅纳米线（SiNW）组成的仿生黏附表面。我们合成了不同修饰比例的 HxGltn（27HxGltn、37HxGltn 和 50HxGltn），并处理了两种不同类型的 SiNW 板（800 间距和 1500 间距），高度为 1400nm，直径为 400nm（分别为 800/1400 SiNW 和 1500/1400 SiNW）。为了增强对肠表面的黏附力，我们将 HxGltn 共价固定在 SiNW 板的表面上。当使用 Gltn、27HxGltn 固定的 800/1400 SiNW、Gltn、27HxGltn、37HxGltn、50HxGltn 固定的 1500/1400 SiNW 时，并未观察到结合强度显著增加。此外，与其他样品相比，37HxGltn 和 50HxGltn 固定的 800/1400 SiNW 仅对肠组织表现出 5 倍更高的结合强度。这些 37HxGltn 和 50HxGltn 固定的 800/1400 SiNW 表面具有应用于软组织黏附的潜力。
