Chen Xi, Taguchi Tetsushi
Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
ACS Omega. 2020 Jan 10;5(3):1519-1527. doi: 10.1021/acsomega.9b03305. eCollection 2020 Jan 28.
Hydrophobically modified poly(vinyl alcohol) (hm-PVA) films with various alkyl chain lengths were prepared. Their surface/mechanical properties, cytocompatibility, and porcine skin adhesion strength were evaluated. hm-PVAs had 10 °C higher glass transition temperature than poly(vinyl alcohol) (PVA) (33.4 ± 2.5 °C). The water contact angle of the hm-PVA films increased with alkyl chain length and/or hydrophobic group modification ratio. The tensile strength of the hm-PVA films decreased with increasing alkyl chain length and/or hydrophobic group modification ratio. hm-PVA with short chain lengths (4 mol % propanal-modified PVA; 4C3-PVA) had low cytotoxicity compared with long alkyl chain length hm-PVAs (4 mol % hexanal and nonanal-modified PVA; 4C6-PVA and 4C9-PVA). The 4C3-PVA film had the highest porcine skin adhesion strength. Thus, the 4C3-PVA film is promising as an adhesive for wearable medical devices.
制备了具有不同烷基链长度的疏水改性聚乙烯醇（hm-PVA）薄膜。对其表面/机械性能、细胞相容性和猪皮粘附强度进行了评估。hm-PVA的玻璃化转变温度比聚乙烯醇（PVA）高10°C（33.4±2.5°C）。hm-PVA薄膜的水接触角随烷基链长度和/或疏水基团改性率的增加而增大。hm-PVA薄膜的拉伸强度随烷基链长度和/或疏水基团改性率的增加而降低。与长烷基链长度的hm-PVA（4 mol%己醛和壬醛改性的PVA；4C6-PVA和4C9-PVA）相比，短链长度的hm-PVA（4 mol%丙醛改性的PVA；4C3-PVA）具有较低的细胞毒性。4C3-PVA薄膜具有最高的猪皮粘附强度。因此，4C3-PVA薄膜有望作为可穿戴医疗设备的粘合剂。
