School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
J Inorg Biochem. 2019 May;194:153-159. doi: 10.1016/j.jinorgbio.2019.02.014. Epub 2019 Feb 27.
In this study, the zinc(II)-based coordination polymer, [Zn(CPDA)(NO))](CPDA = 1,2-cyclopentanedicarboxylic acid) (1), had been successfully synthesized according to the hydrothermal method. Afterwards, 1 had been characterized by means of single crystal and power X-ray diffraction, elemental analysis, thermogravimetric analysis and infrared spectrum techniques. In addition, the antibacterial activities in vitro had been evaluated towards Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively, through the growth inhibition and inhibition zone experimental methods. Our results indicated that 1 had displayed favorable antibacterial activity compared with the Zinc nitrate and the CPDA ligand. These findings had revealed that the antibacterial mechanism of 1 might be correlated with the production of reactive oxygen species (ROS) in cells.
在这项研究中，通过水热法成功合成了基于锌(II)的配位聚合物 Zn(CPDA)(NO))（1）。随后，通过单晶和粉末 X 射线衍射、元素分析、热重分析和红外光谱技术对 1 进行了表征。此外，通过生长抑制和抑菌圈实验方法，分别评估了 1 对大肠杆菌 (E. coli) 和金黄色葡萄球菌 (S. aureus) 的体外抗菌活性。我们的结果表明，1 表现出比硝酸锌和 CPDA 配体更好的抗菌活性。这些发现表明，1 的抗菌机制可能与细胞内活性氧 (ROS) 的产生有关。
