Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany; Vanderbilt University School of Medicine, Nashville, TN, United States.
Adv Carbohydr Chem Biochem. 2019;76:65-111. doi: 10.1016/bs.accb.2018.09.004. Epub 2018 Nov 7.
Sialic acid-based glycoconjugates cover the surfaces of many different cell types, defining key properties of the cell surface such as overall charge or likely interaction partners. Because of this prominence, sialic acids play prominent roles in mediating attachment and entry to viruses belonging to many different families. In this review, we first describe how interactions between viruses and sialic acid-based glycan structures can be identified and characterized using a range of techniques. We then highlight interactions between sialic acids and virus capsid proteins in four different viruses, and discuss what these interactions have taught us about sialic acid engagement and opportunities to interfere with binding.
基于唾液酸的糖缀合物覆盖许多不同细胞类型的表面，定义了细胞表面的关键性质，如整体电荷或可能的相互作用伙伴。正因为如此，唾液酸在介导许多不同家族的病毒的附着和进入方面发挥着重要作用。在这篇综述中，我们首先描述了如何使用一系列技术来识别和表征病毒与基于唾液酸的聚糖结构之间的相互作用。然后，我们重点介绍了四种不同病毒中唾液酸与病毒衣壳蛋白之间的相互作用，并讨论了这些相互作用使我们对唾液酸结合以及干扰结合的机会有了哪些了解。
