1] Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine. [2] Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine. [3].
1] Interfaculty Institute of Biochemistry, University of Tubingen, 72076 Tubingen, Germany. [2] Institute of Complex Systems (ICS.6), Forschungszentrum Julich, 52425 Julich, Germany. [3].
Nat Rev Microbiol. 2014 Nov;12(11):739-49. doi: 10.1038/nrmicro3346. Epub 2014 Sep 29.
Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
病毒感染是由病毒附着在宿主细胞表面受体上引发的，这些受体包括含有唾液酸的聚糖。现在，使用聚糖阵列筛选可以快速识别特定的聚糖受体，定义病毒-聚糖复合物的原子水平结构，并改变聚糖结合位点，以确定聚糖结合在病毒疾病中的功能。这篇综述强调了病毒-聚糖相互作用的一般原则，并提供了具有茎状附着蛋白的病毒（包括流感病毒、呼肠孤病毒、腺病毒和轮状病毒）结合唾液酸的具体实例。了解病毒-聚糖相互作用对于对抗病毒感染和设计用于治疗应用的改良病毒载体至关重要。
