尼古丁对两栖动物皮肤黑素细胞的体外激活作用。

In vitro activation of amphibian dermal melanocytes by nicotine.

作者信息

Hedin C A, Larsson A

出版信息

Scand J Dent Res. 1986 Feb;94(1):57-65. doi: 10.1111/j.1600-0722.1986.tb01364.x.

DOI:10.1111/j.1600-0722.1986.tb01364.x

Abstract

Epidemiologic investigations have shown that nicotine could be a factor causing oral melanin pigmentation in man. Nicotine was therefore tested on amphibian skin melanocytes. Cell reactions were registered by spectrophotometry, in vitro light microscopy, photomicrography and light and electron microscopy. It was found that dermal melanocytes in the toad Bufo bufo and the frog Rana arvalis were activated by nicotine and that this activation was not mediated via beta-adrenergic receptors in melanocytes.

摘要

流行病学调查表明，尼古丁可能是导致人类口腔黑色素沉着的一个因素。因此，对两栖动物皮肤黑色素细胞进行了尼古丁测试。通过分光光度法、体外光学显微镜、摄影以及光学和电子显微镜对细胞反应进行记录。结果发现，蟾蜍（Bufo bufo）和林蛙（Rana arvalis）的真皮黑色素细胞被尼古丁激活，且这种激活不是通过黑色素细胞中的β-肾上腺素能受体介导的。