Hu F, Teramura D J, Mah K
J Invest Dermatol. 1983 Aug;81(2):115-9. doi: 10.1111/1523-1747.ep12542961.
The effects of theophylline and melanocyte-stimulating hormone (MSH) on cultured uveal melanocytes from the eyes of normal adult rhesus macaques were studied by light and electron microscopy and by dopa cytochemistry. The principal effects were changes in melanosome ultrastructure and an increased complexity of Golgi-associated vesicles and cisternae filled with dopa reaction products. The changes were more extensive in iris cells and less remarkable in choroid cells. The effects of theophylline were more pronounced than those of MSH. Our data suggest that normal iridial melanocytes, as do melanogenic murine melanoma cells, respond to theophylline or MSH by increasing tyrosinase synthesis, tyrosinase transfer, and melanization.
通过光学显微镜、电子显微镜以及多巴细胞化学方法，研究了茶碱和促黑素细胞激素（MSH）对来自正常成年恒河猴眼睛的培养葡萄膜黑素细胞的影响。主要影响包括黑素体超微结构的变化，以及充满多巴反应产物的高尔基体相关小泡和扁平囊的复杂性增加。这些变化在虹膜细胞中更广泛，在脉络膜细胞中不太明显。茶碱的作用比MSH更显著。我们的数据表明，正常虹膜黑素细胞与产生黑色素的小鼠黑色素瘤细胞一样，通过增加酪氨酸酶合成、酪氨酸酶转运和黑色素生成来响应茶碱或MSH。
