Haiping Li, Ziqiang Jiang, Qina Zhao, Yuhua Ding
North Twelve Department of Brain Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Sports Injury Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Pak J Pharm Sci. 2019 Jan;32(1(Special)):427-432.
.Fluoroquinolones are a kind of synthetic drugs commonly used in clinical treatment. They have good broad-spectrum antimicrobial properties. They are not only convenient to administer, but also have remarkable therapeutic effects. In this paper, we selected 70 patients with adverse reactions of central nervous system during the use of fluoroquinolones as the research object. We reviewed and analyzed the basic data, main manifestations and outcomes of adverse reactions, and summarized the influencing factors. The results showed that dizziness, irritability and insomnia were the main symptoms in 42 patients with mild adverse reactions. In 28 patients with moderate to severe adverse reactions, neuropsychiatric symptoms such as restlessness, depression, nervous excitation, phonism and hallucination were found. 54 patients were able to recover after stopping the medication. The remaining 16 patients were treated with drugs, and the effective rate was 87.5%. By analyzing the related factors, it can be seen that elderly patients over 60 years old, intravenous administration, combination of drugs and past history of neurological diseases are the main factors leading to adverse reactions of the central nervous system. In this survey, there were 7 kinds of adverse drug reactions, of which 31 cases (44.28%) were caused by levofloxacin. Therefore, fluoroquinolones have adverse effects on the central nervous system in the course of treatment, and the occurrence of adverse reactions is related to patients' age, route of administration, drug combination and past history of illness. It is important to grasp the above factors and make rational use of drugs.
氟喹诺酮类是临床治疗中常用的一类合成药物。它们具有良好的广谱抗菌特性。不仅给药方便，而且治疗效果显著。本文选取70例使用氟喹诺酮类药物过程中出现中枢神经系统不良反应的患者作为研究对象。回顾分析了不良反应的基本资料、主要表现及转归，并总结了影响因素。结果显示，42例轻度不良反应患者的主要症状为头晕、烦躁和失眠。28例中重度不良反应患者出现了躁动、抑郁、神经兴奋、幻听和幻觉等神经精神症状。54例患者停药后得以康复。其余16例患者进行药物治疗，有效率为87.5%。通过分析相关因素可见，60岁以上老年患者、静脉给药、联合用药及既往有神经疾病史是导致中枢神经系统不良反应的主要因素。本次调查中，药物不良反应有7种，其中31例（44.28%）由左氧氟沙星引起。因此，氟喹诺酮类药物在治疗过程中对中枢神经系统有不良影响，不良反应的发生与患者年龄、给药途径、药物联用及既往病史有关。掌握上述因素并合理用药很重要。
