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双侧单纯疱疹性角膜炎:哺乳期为复发诱因!

Bilateral herpes simplex keratitis: lactation a trigger for recurrence!

作者信息

Agarwal Rinky, Maharana Prafulla Kumar, Titiyal Jeewan S, Sharma Namrata

机构信息

Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

出版信息

BMJ Case Rep. 2019 Mar 9;12(3):e223713. doi: 10.1136/bcr-2017-223713.

Abstract

A young lactating woman presenting to us with simultaneous bilateral corneal lesions was clinically diagnosed to have herpes simplex keratitis, which was confirmed by herpes simplex virus (HSV) PCR. The patient was administered topical and systemic acyclovir therapy and therapeutic penetrating keratoplasty was done in right eye. She was advised to continue breast feeding under strict hygienic conditions. Diagnosis and management of HSV keratitis in a lactating patient can be particularly challenging for both clinician and patient and adoption of a multidisciplinary approach is necessary to ensure safety of mother and child. At 3 months follow-up, the baby was clinically healthy, there were no side effects of acyclovir therapy in the mother or the baby and the patient showed no evidence of recurrence in either eye.

摘要

一名前来就诊的年轻哺乳期妇女双眼同时出现角膜病变,临床诊断为单纯疱疹性角膜炎,单纯疱疹病毒(HSV)聚合酶链反应(PCR)检测结果证实了该诊断。患者接受了局部和全身阿昔洛韦治疗,并对右眼进行了治疗性穿透性角膜移植术。建议她在严格的卫生条件下继续母乳喂养。对于临床医生和患者而言,哺乳期患者的HSV角膜炎诊断和管理都极具挑战性,因此必须采用多学科方法以确保母婴安全。在3个月的随访中,婴儿临床健康,母亲和婴儿均未出现阿昔洛韦治疗的副作用,且患者双眼均无复发迹象。

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[The Chameleon of Herpetic Keratitis - Diagnosis and Therapy].[疱疹性角膜炎的变色龙——诊断与治疗]
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本文引用的文献

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Herpes Simplex Virus Disease of the Anterior Segment in Children.儿童眼前节单纯疱疹病毒病
Cornea. 2015 Oct;34 Suppl 10:S68-71. doi: 10.1097/ICO.0000000000000559.
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Herpes simplex epithelial and stromal keratitis: an epidemiologic update.单纯疱疹性上皮和基质角膜炎:流行病学更新。
Surv Ophthalmol. 2012 Sep;57(5):448-62. doi: 10.1016/j.survophthal.2012.01.005. Epub 2012 Apr 28.
6
Herpes simplex virus keratitis in children.儿童单纯疱疹病毒性角膜炎
Am J Ophthalmol. 2004 Sep;138(3):474-5. doi: 10.1016/j.ajo.2004.04.027.
7
Bilateral herpetic keratoconjunctivitis.双侧疱疹性角膜结膜炎
Ophthalmology. 2003 Mar;110(3):493-6. doi: 10.1016/S0161-6420(02)01772-4.
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Acyclovir excretion in human breast milk.
Ann Pharmacother. 1994 May;28(5):585-7. doi: 10.1177/106002809402800506.

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