终生感染 HIV 的年轻人中肝脂肪变性的患病率增加。
Increased Prevalence of Hepatic Steatosis in Young Adults With Lifelong HIV.
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Departments of Critical Care Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.
出版信息
J Infect Dis. 2019 Jun 19;220(2):266-269. doi: 10.1093/infdis/jiz096.
Abstract
Little is known about the effects of lifelong human immunodeficiency virus (HIV) or antiretroviral therapy on hepatic steatosis and fibrosis. Using transient elastography, we evaluated 46 young adults with lifelong HIV and 20 matched HIV-negative controls. Steatosis was present in 33% of persons with HIV and only 10% of controls (P = .04). Hepatic fibrosis scores were not elevated and did not differ between groups. Metabolic parameters, particularly increased waist circumference, and not HIV-specific factors, were significantly associated with steatosis. While this finding should be examined in larger cohorts, modifiable metabolic disturbances may be important targets to optimize liver health in this population.
摘要
关于终身人类免疫缺陷病毒 (HIV) 或抗逆转录病毒治疗对肝脂肪变性和纤维化的影响知之甚少。我们使用瞬时弹性成像技术评估了 46 名患有终身 HIV 的年轻成年人和 20 名匹配的 HIV 阴性对照者。33%的 HIV 感染者存在脂肪变性，而对照组仅为 10%（P =.04）。两组的肝纤维化评分均不高且无差异。代谢参数，特别是腰围增加，而不是 HIV 特异性因素，与脂肪变性显著相关。虽然这一发现需要在更大的队列中进行检查，但可改变的代谢紊乱可能是优化该人群肝脏健康的重要目标。
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