早期社会情感行为与自闭症谱系障碍的关系：高危兄弟姐妹研究。

Relationship Between Early Social-Emotional Behavior and Autism Spectrum Disorder: A High-Risk Sibling Study.

机构信息

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Autism Research Centre (E209), Glenrose Rehabilitation Hospital, 10230 - 111 Avenue, Edmonton, AB, T5G 0B7, Canada.

出版信息

J Autism Dev Disord. 2020 Jul;50(7):2527-2539. doi: 10.1007/s10803-019-03977-3.

DOI:10.1007/s10803-019-03977-3

PMID:30852785

Abstract

Social-emotional behavior in autism spectrum disorder (ASD) was examined among high-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers. Caregivers completed the Infant-Toddler Social Emotional Assessment (ITSEA) at 18 months, and blind diagnostic assessment for ASD was conducted at 36 months. Results indicated impairment in social-emotional functioning among HR toddlers subsequently diagnosed with ASD compared to other HR and LR toddlers, such that ITSEA domains (Internalizing, Dysregulation, Competence) and subdomains predicted later ASD symptoms and diagnosis. Receiver operating curves of optimal ITSEA cutoffs ranged from 0.23 to 0.44 for sensitivity, and 0.74 to 0.89 for specificity. Although classification accuracy for ASD was limited, group differences highlight the importance of considering social-emotional development when assessing ASD risk.

摘要

自闭症谱系障碍（ASD）患儿的社会情绪行为在高风险（HR；自闭症患儿的兄弟姐妹）和低风险（LR；无 ASD 家族史）幼儿中进行了研究。在 18 个月时，看护者完成了婴儿-幼儿社会情感评估（ITSEA），并在 36 个月时进行了盲法诊断评估 ASD。结果表明，与其他 HR 和 LR 幼儿相比，随后被诊断为 ASD 的 HR 幼儿在社会情感功能方面存在障碍，因此 ITSEA 领域（内化、失调、能力）和子领域预测了日后的 ASD 症状和诊断。最佳 ITSEA 截断值的受试者工作特征曲线的灵敏度范围为 0.23 至 0.44，特异性范围为 0.74 至 0.89。尽管 ASD 的分类准确性有限，但组间差异突出了在评估 ASD 风险时考虑社会情感发展的重要性。