Fernandez-Pittol Mariana J, Alejo-Cancho Izaskun, Rubio Elisa, López Miriam, García Adriana, Mascaro José Manuel, Marco Francesc, Vila Jordi, Puig de la Bellacasa Jorge
Department of Microbiology, Hospital Clínic, Universitat de Barcelona, ISGLOBAL, Barcelona, Spain.
Department of Microbiology, Hospital Clínic, Universitat de Barcelona, ISGLOBAL, Barcelona, Spain.
Rev Iberoam Micol. 2019 Apr-Jun;36(2):90-92. doi: 10.1016/j.riam.2018.10.003. Epub 2019 Mar 8.
Phaeoacremonium parasiticum is considered a rare infectious agent that is part of a heterogeneous group of fungi causing phaeohyphomycosis. This organism is capable of producing subcutaneous infections, eumycetomas, osteomyelitis, arthritis, myositis and also disseminated diseases, such as fungemia and endocarditis.
We describe a case of cutaneous infection by P. parasiticum in a kidney transplant patient. The identification of this microorganism was performed by microbiological and histopathological studies and confirmed with the sequence of the gene encoding β-tubulin and a real time panfungal PCR targeting 18S ribosomal RNA gene. The microorganism was correctly identified by phenotypic and molecular methods. The patient was treated with oral antifungal therapy and a debulking surgery and evolved without any complication.
The diagnosis of this infection is difficult and usually affects kidney transplant patients, but the reasons of this association are still unknown.
寄生拟青霉被认为是一种罕见的感染病原体，是引起暗色丝孢霉病的一组异质性真菌的一部分。这种微生物能够引起皮下感染、真菌瘤、骨髓炎、关节炎、肌炎，还能引起播散性疾病，如真菌血症和心内膜炎。
我们描述了一例肾移植患者发生寄生拟青霉皮肤感染的病例。通过微生物学和组织病理学研究对该微生物进行鉴定，并通过编码β-微管蛋白的基因序列和靶向18S核糖体RNA基因的实时泛真菌PCR进行确认。通过表型和分子方法正确鉴定了该微生物。患者接受了口服抗真菌治疗和减瘤手术，病情进展无任何并发症。
这种感染的诊断困难，且通常影响肾移植患者，但其关联原因仍不清楚。
