Frith Emily, Loprinzi Paul D
Physical Activity Epidemiology and Exercise Psychology Laboratories, Department of Health, Exercise Science and Recreation Management, University of Mississippi, University, MS.
Diabetes Spectr. 2019 Feb;32(1):16-20. doi: 10.2337/ds18-0002.
We evaluated the specific association between muscle-strengthening activity (MSA) and accelerometer-assessed physical activity on systemic inflammation among retinopathy patients in the United States.
Data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) were used to identify 157 retinopathy patients between 40 and 85 years of age with complete data on select study variables. MSA was assessed via self-report. Participation in moderate-to-vigorous physical activity (MVPA) was determined from objective accelerometer data. Systemic inflammation was assessed using C-reactive protein (CRP), which was quantified using latex-enhanced nephelometry. Nonproliferative retinopathy was determined using Early Treatment Diabetic Retinopathy Study grading criteria, as well as objective retinal imaging assessments using the Canon Non-Mydriatic Retinal Camera CR6-45NM. Individuals were excluded if they had been diagnosed with coronary artery disease, congestive heart failure, heart attack, or stroke.
MVPA (β = -0.004, 95% CI -0.007 to -0.001, = 0.006) but not MSA (β = -0.0001, 95% CI -0.002 to 0.001, = 0.86) was associated with lower CRP levels. Additionally, for a more substantive 30 minutes/day increase in MVPA, there was a corresponding 0.12 mg/dL decrease in CRP.
In this nationally representative sample of adults, only individuals who engaged in higher levels of MVPA had lower CRP levels, which is indicative of reduced systemic inflammation. MSA was not associated with systemic inflammation among this cohort. Our findings suggest that MVPA is inversely associated with systemic inflammation among retinopathy patients, which is noteworthy because increased systemic inflammation may facilitate retinopathic severity.
我们评估了在美国视网膜病变患者中，肌肉强化活动（MSA）和通过加速度计评估的身体活动与全身炎症之间的具体关联。
使用2005 - 2006年国家健康和营养检查调查（NHANES）的数据，确定了157名年龄在40至85岁之间的视网膜病变患者，这些患者具有选定研究变量的完整数据。MSA通过自我报告进行评估。中度至剧烈身体活动（MVPA）的参与情况根据客观的加速度计数据确定。使用C反应蛋白（CRP）评估全身炎症，通过乳胶增强散射比浊法对其进行定量。使用早期糖尿病性视网膜病变研究分级标准以及使用佳能免散瞳视网膜相机CR6 - 45NM进行的客观视网膜成像评估来确定非增殖性视网膜病变。如果个体被诊断患有冠状动脉疾病、充血性心力衰竭、心脏病发作或中风，则将其排除。
MVPA（β = -0.004，95%CI -0.007至 -0.001，P = 0.006）与较低的CRP水平相关，但MSA（β = -0.0001，95%CI -0.002至0.001，P = 0.86）与较低的CRP水平无关。此外，MVPA每天实质性增加30分钟，CRP相应降低0.12mg/dL。
在这个具有全国代表性的成人样本中，只有进行较高水平MVPA的个体具有较低的CRP水平，这表明全身炎症减轻。在该队列中，MSA与全身炎症无关。我们的研究结果表明，MVPA与视网膜病变患者的全身炎症呈负相关，这值得注意，因为全身炎症增加可能会促进视网膜病变的严重程度。
