Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi, University, MS.
Center for Health Behavior Research, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi, University, MS.
Mayo Clin Proc. 2016 Feb;91(2):166-74. doi: 10.1016/j.mayocp.2015.10.017. Epub 2015 Dec 23.
To determine whether the behavioral participation in muscle-strengthening activity (MSA) or the strength outcome produces the largest reduction in all-cause mortality risk.
The 1999-2002 National Health and Nutritional Examination Survey was used, with follow-up of up to 12.6 years (mean, 9.9 years) (N=2773 adults aged ≥50 years). Participants were placed into 4 groups based on 2 dichotomously categorized variables: lower-extremity strength (LES) of the knee extensors (top quartile) and adherence to MSA guidelines (≥2 MSA sessions per week). Approximately 21% of the population died during follow-up.
Compared with individuals not meeting MSA guidelines and not in top quartile for LES, the adjusted hazard ratios (HRs) and 95% CIs were as follows: (1) meets MSA guidelines but not in top quartile for LES (HR=0.96; 95% CI, 0.63-1.45; P=.84), (2) in top quartile for LES but does not meet MSA guidelines (HR=0.54; 95% CI, 0.42-0.71; P<.001), and (3) in top quartile for LES and meets MSA guidelines (HR=0.28; 95% CI, 0.12-0.66; P=.005). Further analyses revealed that individuals in the top quartile for LES who also met MSA and moderate to vigorous physical activity guidelines were at even further reduced risk for premature all-cause mortality (HR=0.23; 95% CI, 0.08-0.61; P=.005).
These results demonstrate that muscle strength seems to be more important than the behavioral participation in MSA for reducing the risk of premature all-cause mortality.
确定是肌肉强化活动（MSA）的行为参与度还是力量结果对全因死亡率风险的降低影响最大。
使用了 1999-2002 年全国健康和营养调查，随访时间长达 12.6 年（平均 9.9 年）（N=2773 名年龄≥50 岁的成年人）。参与者根据 2 个二分变量被分为 4 组：膝关节伸肌的下肢力量（上四分位数）和遵守 MSA 指南（每周≥2 次 MSA 运动）。在随访期间，大约 21%的人群死亡。
与不符合 MSA 指南且下肢力量不在上四分位数的个体相比，调整后的危险比（HR）和 95%置信区间（CI）如下：（1）符合 MSA 指南但下肢力量不在上四分位数（HR=0.96；95%CI，0.63-1.45；P=.84），（2）下肢力量在上四分位数但不符合 MSA 指南（HR=0.54；95%CI，0.42-0.71；P<.001），和（3）下肢力量在上四分位数且符合 MSA 指南（HR=0.28；95%CI，0.12-0.66；P=.005）。进一步分析表明，下肢力量在上四分位数且符合 MSA 和中等到剧烈体力活动指南的个体，过早全因死亡率的风险进一步降低（HR=0.23；95%CI，0.08-0.61；P=.005）。
这些结果表明，肌肉力量似乎比 MSA 的行为参与对降低过早全因死亡率的风险更为重要。
