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儿童中的炎症:移民优势的证据?

Inflammation among Children: Evidence of an Immigrant Advantage?

作者信息

Schmeer Kammi K

出版信息

Adv Med Sociol. 2019;19:275-295.

Abstract

Past research on the immigrant health paradox suggests that children with immigrant parents may have a health advantage over those with U.S.-born parents, especially if the parent is a recent immigrant. Other research emphasizes the social and economic challenges children with immigrant parents face, in part due to disadvantaged social class and racial/ethnic positions. Underlying physiological changes due to chronic stress exposures among children in immigrant families is one potential health disadvantage that may not yet be apparent in traditional health measures. To explore these biological disparities during childhood, I use national biomarker and survey data from NHANES (N=11,866) to evaluate parent nativity and educational status associations with low-grade inflammation, indicated by C-reactive Protein (CRP), in children ages 2-15 years. I find that children with an immigrant parent, and particularly a low-education immigrant parent, have higher CRP, net of birth, BMI and other factors, than children with a U.S. born parent with either a low or higher education. Comparing children with low-educated parents, those with a foreign-born parent have higher predicted CRP. The findings from this study provide new evidence that children living in immigrant families in the U.S. may be facing higher levels of chronic stress exposure, as indicated by the increased risk of low-grade inflammation, than those with U.S.-born parents. The physiological changes related to increased risk of inflammation could set children in immigrant families on pathways towards mental and physical health problems throughout childhood and later in the life course.

摘要

过去关于移民健康悖论的研究表明,父母为移民的孩子可能比父母在美国出生的孩子具有健康优势,尤其是如果父母是新移民。其他研究强调了父母为移民的孩子所面临的社会和经济挑战,部分原因是社会阶层不利以及种族/族裔地位。移民家庭中的孩子因长期暴露于压力下而产生的潜在生理变化是一个潜在的健康劣势,这在传统的健康指标中可能尚不明显。为了探究童年时期的这些生物学差异,我使用了来自美国国家健康与营养检查调查(NHANES,N = 11,866)的国家生物标志物和调查数据,来评估2至15岁儿童中父母出生地和教育状况与由C反应蛋白(CRP)表示的低度炎症之间的关联。我发现,父母为移民的孩子,尤其是父母教育程度低的移民孩子,在扣除出生、体重指数和其他因素后,其CRP水平高于父母在美国出生且教育程度低或高的孩子。比较父母教育程度低的孩子,父母为外国出生的孩子预测的CRP水平更高。这项研究的结果提供了新的证据,表明生活在美国移民家庭中的孩子可能比父母在美国出生的孩子面临更高水平的长期压力暴露,这表现为低度炎症风险增加。与炎症风险增加相关的生理变化可能使移民家庭中的孩子在整个童年及以后的人生过程中走上心理健康和身体健康问题的道路。

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本文引用的文献

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Soc Sci Res. 2016 Nov;60:236-248. doi: 10.1016/j.ssresearch.2016.04.001. Epub 2016 Apr 6.
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Socioeconomic status inequalities in low-grade inflammation during childhood.儿童期低度炎症中的社会经济地位不平等
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