Kim Do Eon, Cho Chang-Hoon, Sim Kyoung Mi, Kwon Osung, Hwang Eun Mi, Kim Hyung-Wook, Park Jae-Yong
College of Life Sciences, Sejong University, Seoul 05006, Korea.
School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 02708, Korea.
Exp Neurobiol. 2019 Feb;28(1):43-53. doi: 10.5607/en.2019.28.1.43. Epub 2019 Jan 30.
14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.
14 - 3 - 3γ在细胞过程的不同方面发挥着多种作用。特别是在富含14 - 3 - 3γ的大脑中，据报道它与神经和精神疾病（如威廉姆斯 - 博伦综合征和克雅氏病）有关。然而，与14 - 3 - 3γ缺乏相关的行为异常在很大程度上尚不清楚。在这里，通过使用14 - 3 - 3γ基因缺陷小鼠，我们发现纯合敲除小鼠在出生前是致死的，杂合小鼠相对于野生型同窝小鼠表现出发育延迟。此外，在行为分析中，我们发现14 - 3 - 3γ杂合子小鼠表现出多动和抑郁样行为，并且对急性应激的反应比同窝对照小鼠更敏感。这些结果表明14 - 3 - 3γ水平可能参与相关神经精神疾病的发育表现。此外，14 - 3 - 3γ杂合子小鼠可能是研究神经精神症状分子病理生理学的潜在模型。
