Department of Physiology and Biophysics (M/C 901) and Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 South Wolcott Avenue, RM E-202, Chicago, IL, 60612, USA.
Pflugers Arch. 2022 Mar;474(3):267-279. doi: 10.1007/s00424-021-02635-x. Epub 2021 Nov 25.
14-3-3 proteins (14-3-3 s) are a family of highly conserved proteins that regulate many cellular processes in eukaryotes by interacting with a diverse array of client proteins. The 14-3-3 proteins have been implicated in several disease states and previous reviews have condensed the literature with respect to their structure, function, and the regulation of different cellular processes. This review focuses on the growing body of literature exploring the important role 14-3-3 proteins appear to play in regulating the biochemical and biophysical events associated with excitation-contraction coupling (ECC) in muscle. It presents both a timely and unique analysis that seeks to unite studies emphasizing the identification and diversity of 14-3-3 protein function and client protein interactions, as modulators of muscle contraction. It also highlights ideas within these two well-established but intersecting fields that support further investigation with respect to the mechanistic actions of 14-3-3 proteins in the modulation of force generation in muscle.
14-3-3 蛋白（14-3-3s）是一类高度保守的蛋白家族，通过与各种不同的客户蛋白相互作用，调节真核生物中的许多细胞过程。14-3-3 蛋白与多种疾病状态有关，以前的综述已经对其结构、功能以及不同细胞过程的调控进行了文献综述。本文重点关注不断增加的文献，探讨 14-3-3 蛋白在调节与肌肉兴奋-收缩偶联（ECC）相关的生化和生物物理事件中所起的重要作用。本文提出了一个及时而独特的分析，试图将强调鉴定和多样性的 14-3-3 蛋白功能和客户蛋白相互作用的研究，以及作为肌肉收缩调节剂的研究统一起来。它还强调了这两个成熟但相互交叉的领域中的一些观点，这些观点支持进一步研究 14-3-3 蛋白在调节肌肉力量产生中的机械作用。
