Krimmel Samuel R, Qadir Houman, Hesselgrave Natalie, White Michael G, Reser David H, Mathur Brian N, Seminowicz David A
Center to Advance Chronic Pain Research, Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD, United States.
Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD, United States.
Front Neuroanat. 2019 Feb 22;13:22. doi: 10.3389/fnana.2019.00022. eCollection 2019.
The claustrum is structurally connected with many cortical areas.A major hurdle standing in the way of understanding claustrum function is the difficulty in assessing the global functional connectivity (FC) of this structure. The primary issues lie in the inability to isolate claustrum signal from the adjacent insular cortex (Ins), caudate/putamen (CPu), and endopiriform nucleus (Endo). To address this issue, we used (7T) fMRI in the rat and describe a novel analytic method to study claustrum without signal contamination from the surrounding structures. Using this approach, we acquired claustrum signal distinct from Ins, CPu, and Endo, and used this claustrum signal to determine whole brain resting state functional connectivity (RSFC). Claustrum RSFC was distinct from the adjacent structures and displayed extensive connections with sensory cortices and the cingulate cortex, consistent with known structural connectivity of the claustrum. These results suggest fMRI and improved analysis can be combined to accurately assay claustrum function.
屏状核在结构上与许多皮质区域相连。理解屏状核功能的一个主要障碍是难以评估该结构的整体功能连接性（FC）。主要问题在于无法将屏状核信号与相邻的岛叶皮质（Ins）、尾状核/壳核（CPu）和内梨状核（Endo）区分开来。为了解决这个问题，我们在大鼠中使用了7T功能磁共振成像（fMRI），并描述了一种新的分析方法来研究屏状核，而不会受到周围结构信号污染的影响。使用这种方法，我们获取了与Ins、CPu和Endo不同的屏状核信号，并使用该屏状核信号来确定全脑静息态功能连接性（RSFC）。屏状核的RSFC与相邻结构不同，并与感觉皮质和扣带回皮质显示出广泛的连接，这与屏状核已知的结构连接性一致。这些结果表明，功能磁共振成像和改进的分析方法可以结合起来，以准确测定屏状核的功能。
