Vetkova L G, Zaĭtsev L G, Khasman E L, Radkevich S A, Moroz A F
Zh Mikrobiol Epidemiol Immunobiol. 1986 Mar(3):14-8.
The prophylactic effect of immunization with P. aeruginosa polyvalent corpuscular vaccine has been shown on the model of P. aeruginosa generalized chronic infection in mice with leukopenia induced by the intraperitoneal injection of cyclophosphamids. This effect is manifested by the increased resistance of the animals to sublethal doses of P. aeruginosa strain, as well as by more intense general and specific immunological responses in the infected animals (the increase of specific antibody titers, the number of leukocytes in the blood serum and the phagocytic activity of the cells of peritoneal exudate).
在通过腹腔注射环磷酰胺诱导白细胞减少的小鼠铜绿假单胞菌全身性慢性感染模型上，已证实接种铜绿假单胞菌多价微粒疫苗具有预防作用。这种作用表现为动物对亚致死剂量铜绿假单胞菌菌株的抵抗力增强，以及感染动物的全身和特异性免疫反应更强烈（特异性抗体滴度增加、血清中白细胞数量增加以及腹腔渗出液细胞的吞噬活性增强）。
