Endocrine, Nutritional and Metabolic Diseases Group, CICA-Centro Interdisciplinar de Química e Bioloxía, Universidade de A Coruña, As Carballeiras, s/n, Campus de Elviña, 15071 A Coruña, Spain.
Endocrine, Nutritional and Metabolic Diseases Group, Department of Physiotherapy, Medicine and Biomedical Sciences, Faculty of Physiotherapy, Universidade de A Coruña, Campus de Oza, 15006 A Coruña, Spain.
Int J Mol Sci. 2022 Dec 13;23(24):15792. doi: 10.3390/ijms232415792.
microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families have been identified as key players in adipogenesis. Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. In vitro experiments identified miR-19a and b as crucial actors in adipogenesis and lipid accumulation. Overall, our results suggest a novel role of the miR-19 family in the regulatory networks underlying adipogenesis and, therefore, adipose tissue dysfunction.
微小 RNA（miRNA）是一类小的内源性 RNA，在肥胖症发展过程中脂肪细胞的分化和功能中发挥关键作用。尽管如此，只有少数 miRNA 家族被确定为脂肪生成中的关键因子。在这里，我们展示了 miR-19 家族，miR-19a 和 miR-19b，在脂质积累和肥胖症中脂肪组织扩张中的相关性。我们观察到，miR-19s 在病态肥胖患者的腹部皮下脂肪组织（aSAT）中上调，而在减肥手术后，其表达降低。体外实验确定 miR-19a 和 b 是脂肪生成和脂质积累的关键因素。总的来说，我们的结果表明 miR-19 家族在脂肪生成的调控网络中具有新的作用，因此，也与脂肪组织功能障碍有关。
