Zhu Tian, Guo Wei-Hua
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2019 Feb 1;37(1):92-96. doi: 10.7518/hxkq.2019.01.018.
Lesions on tissues and organs critically affect quality of life, due to severe tissue defects that are threatening. Tissue repair and functional reconstruction are concurrent challenges in modern medicine. Tissue engineering brings hope for tissue and organ regeneration. Scaffolds provide a microenvironment for cell growth, proliferation and differentiation. Moreover, scaffolds influence the size and morphology of regenerated tissues. Dentin matrix, which is a natural bioactive and biocompatible scaffold, has become a research hotspot in recent years and has been widely used in tissue engineering. Studies on the use of dentin matrix as scaffolds have made a series of important progress in tooth root, periodontal, dental pulp and bone regeneration. This review demonstrates the biological characteristics of dentin matrix as bioactive scaffolds, describes the application of dentin matrix in tissue regeneration and provides a theoretical basis for the use of a dentin matrix in clinical applications.
组织和器官上的损伤会严重影响生活质量，因为严重的组织缺损具有威胁性。组织修复和功能重建是现代医学面临的共同挑战。组织工程为组织和器官再生带来了希望。支架为细胞生长、增殖和分化提供微环境。此外，支架会影响再生组织的大小和形态。牙本质基质作为一种天然的生物活性和生物相容性支架，近年来已成为研究热点，并已广泛应用于组织工程。关于使用牙本质基质作为支架的研究在牙根、牙周、牙髓和骨再生方面取得了一系列重要进展。本文综述阐述了牙本质基质作为生物活性支架的生物学特性，描述了牙本质基质在组织再生中的应用，并为牙本质基质在临床应用中的使用提供理论依据。
