The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211004940. doi: 10.1177/15330338211004940.
Long noncoding RNAs (lncRNAs) are noncoding RNAs longer than 200 nt that have almost no function for encoding proteins. As an important regulatory molecule of the human genome, lncRNAs play a regulatory role in the human body. LncRNAs have a variety of functions, such as signaling, guiding, baiting or scaffolding of functional proteins, and are closely related to tumor development. Gastric cancer is one of the most common malignant tumors. It has a high incidence, a low early diagnosis rate, and a poor prognosis, and it seriously threatens human health. Abnormal expression of lncRNAs can affect the occurrence, development, invasion and metastasis of gastric cancer. Therefore, lncRNAs are expected to become important biomarkers and new targets for the diagnosis and treatment of gastric cancer. LncRNAs have a significant potential to guide the diagnosis, treatment and prognosis of gastric cancer. This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors.
长链非编码 RNA（lncRNA）是长度大于 200nt 的非编码 RNA，几乎没有编码蛋白质的功能。作为人类基因组的重要调控分子，lncRNA 在人体中发挥着调控作用。lncRNA 具有多种功能，如信号转导、功能蛋白的导向、诱饵或支架作用，与肿瘤的发生发展密切相关。胃癌是最常见的恶性肿瘤之一，其发病率高，早期诊断率低，预后差，严重威胁人类健康。lncRNA 的异常表达可影响胃癌的发生、发展、侵袭和转移。因此，lncRNA 有望成为胃癌诊断和治疗的重要生物标志物和新靶点。lncRNA 具有指导胃癌诊断、治疗和预后的巨大潜力。本文综述了近年来发现的与胃肠道肿瘤相关的 lncRNA 及其作用机制。
