Department of Zoology, Faculty of Science, Menoufia University, Al Minufya, Egypt.
Department of Biology, College of Sciences, University of Hail, Hail, Saudi Arabia.
Curr Drug Metab. 2019;20(4):283-291. doi: 10.2174/1389200220666190308134351.
Nanotechnology-based therapies are emerging as a promising new anticancer approach. Early clinical studies suggest that nanoparticle-based therapeutics can show enhanced efficacy while reducing side effects minimal, owing to targeted delivery and active intracellular uptake.
To overcome the problems of gene and drug delivery, nanotechnology based delivery system gained interest in the last two decades. Encouraging results from Nano formulation based drug delivery systems revealed that these emerging restoratives can efficiently lead to more effective, targeted, selective and efficacious delivery of chemotherapeutic agents to the affected target cells.
Nanotechnology not only inhibits targeted gene products in patients with cancer, but also taught us valuable lessons regarding appropriate dosages and route of administrations. Besides, nanotechnology based therapeutics holds remarkable potential as an effective drug delivery system. We critically highlight the recent findings on nanotechnology mediated therapeutics strategies to combat hepatocellular carcinoma and discuss how nanotechnology platform can have enhanced anticancer effects compared with the parent therapeutic agents they contain.
In this review, we discussed the key challenges, recent findings and future perspective in the development of effective nanotechnology-based cancer therapeutics. The emphasis here is focused on nanotechnology-based therapies that are likely to affect clinical investigations and their implications for advancing the treatment of patients with hepatocellular carcinoma.
基于纳米技术的疗法作为一种有前途的新型抗癌方法正在兴起。早期的临床研究表明，由于靶向递送和主动细胞内摄取，基于纳米颗粒的疗法可以在提高疗效的同时将副作用降至最低。
为了克服基因和药物递送的问题，基于纳米技术的递药系统在过去二十年中引起了人们的兴趣。基于纳米制剂的药物递送系统的令人鼓舞的结果表明，这些新兴的修复剂可以有效地将化疗药物更有效地、靶向地、选择性地和有效地递送到受影响的靶细胞。
纳米技术不仅抑制了癌症患者的靶向基因产物，还为我们提供了关于适当剂量和给药途径的宝贵经验。此外，基于纳米技术的治疗具有作为有效药物递送系统的显著潜力。我们批判性地强调了纳米技术介导的治疗策略在治疗肝细胞癌方面的最新发现，并讨论了纳米技术平台如何与它们所含的母体治疗剂相比具有增强的抗癌效果。
在这篇综述中，我们讨论了开发有效的基于纳米技术的癌症治疗方法的关键挑战、最新发现和未来展望。重点是可能影响临床研究及其对推进肝细胞癌患者治疗的基于纳米技术的治疗方法。
