Minkoff H, Mead P
Am J Obstet Gynecol. 1986 May;154(5):973-7. doi: 10.1016/0002-9378(86)90731-3.
Group B beta-hemolytic streptococcus is one of the most common causes of neonatal sepsis. Despite its relationship to neonatal morbidity and mortality, no consensus exists for an approach to its prevention. Several characteristics of the organism such as high maternal carriage rates, the intermittent nature of this carriage, and the failure of antibiotics to permanently eliminate carriage have limited the success of proposed intervention protocols. In this clinical opinion we review characteristics of the organism and previously suggested intervention protocols. Then, based on this review and an analysis of recently published data, a protocol focusing on preterm births is presented. This proposal favors intrapartum treatment of all mothers who are delivered of preterm infants and who are either carriers of group B beta-hemolytic streptococci or whose carriage status is unknown. A comparison of the costs and benefits of this and other approaches is made.
B族β溶血性链球菌是新生儿败血症最常见的病因之一。尽管它与新生儿发病和死亡有关，但对于其预防方法尚无共识。该病原体的几个特征，如产妇携带率高、携带的间歇性以及抗生素无法永久消除携带状态，限制了所提议干预方案的成功实施。在本临床观点中，我们回顾了该病原体的特征以及先前建议的干预方案。然后，基于这一回顾和对近期发表数据的分析，提出了一项针对早产的方案。该提议主张对所有分娩早产儿且是B族β溶血性链球菌携带者或携带状态不明的母亲进行产时治疗。并对该方案与其他方法的成本效益进行了比较。
