Wu Peng, Chen Yuanguo, Zhang Haibo, Li Chen
Department of Cardiology, The People's Hospital of Ya'an, Sichuan, China.
Medicine (Baltimore). 2019 Mar;98(10):e14532. doi: 10.1097/MD.0000000000014532.
Idiopathic hypereosinophilic syndrome (IHES) is a rare disease in which patients which present with eosinophilia-associated damage. Previous studies focused on organ damage from increased eosinophilic granulocytosis. We report IHES in a patient who presented with multiple organ damage (MOD).
A 52-year-old male presented with MOD, including myocardial damage suggestive of myocardial infarction, cardiac tamponade, respiratory failure, skin damage, and gastrointestinal damage.
The absolute eosinophil count was 12,920/mm, much higher than occurs in other diseases associated with eosinophilia (1500/mm), and suggesting a diagnosis of IHES.
Prednisone combined with hydroxyurea.
At 6 months after completion of drug treatment, the patient had no chest pain or dyspnea, and the results of a blood panel, chest computed tomography, and gastroscopy were normal.
MOD is very rare in patients with IHES. Patients receiving prompt diagnosis and treatment have very good prognoses.
特发性高嗜酸性粒细胞综合征（IHES）是一种罕见疾病，患者会出现与嗜酸性粒细胞增多相关的损害。既往研究聚焦于嗜酸性粒细胞增多症导致的器官损害。我们报告了一例出现多器官损害（MOD）的IHES患者。
一名52岁男性出现多器官损害，包括提示心肌梗死的心肌损害、心脏压塞、呼吸衰竭、皮肤损害和胃肠道损害。
绝对嗜酸性粒细胞计数为12920/mm，远高于其他与嗜酸性粒细胞增多相关疾病的水平（1500/mm），提示诊断为IHES。
泼尼松联合羟基脲。
药物治疗结束6个月后，患者无胸痛或呼吸困难，血常规、胸部计算机断层扫描和胃镜检查结果均正常。
MOD在IHES患者中非常罕见。及时诊断和治疗的患者预后非常好。
