Wang Yong-Chun, Weng Guo-Peng, Liu Jian-Ping, Li Lei, Cheng Qing-Hong
Department of Medical College, Shihezi University.
Department of Critical Care Medicine, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Medicine (Baltimore). 2019 Mar;98(10):e14756. doi: 10.1097/MD.0000000000014756.
To investigate the changes and significance of IL-37 in patients with sepsis.A total of 50 patients with sepsis between September 2016 and October 2017 at the intensive care unit (ICU) of the First Affiliated Hospital of Shihezi University School of Medicine were selected as the sepsis group, 30 age and sex-matched healthy controls were selected as the control group. The levels of IL-37 in serum were measured by enzyme-linked immunosorbent assay (ELISA) on day 1 and day 7 of the sepsis patients.The levels of serum IL-37 in the sepsis group on day 1 [(39.13 ± 34.35)pg/mL] were significantly higher than that in the control group [(23.75 ± 2.52)pg/mL] with significant difference (P <.05). The levels of IL-37 in the sepsis group after treatment [(30.57 ± 11.01)pg/mL] on day 7 were obviously lower than that before treatment without statisticaly difference (P >.05). A correlation analysis showed that the levels of serum IL-37 and IL-1β were positively correlated.The level of IL-37 observed in sepsis was found to correlate with the severity of the inflammatory reaction. IL-37 could be an important cytokine in the control of sepsis by suppressing the production of pro-inflammatory cytokines.
探讨脓毒症患者白细胞介素-37（IL-37）的变化及其意义。选取2016年9月至2017年10月在石河子大学医学院第一附属医院重症监护病房（ICU）的50例脓毒症患者作为脓毒症组，选取30例年龄、性别匹配的健康对照者作为对照组。采用酶联免疫吸附测定法（ELISA）检测脓毒症患者第1天和第7天血清中IL-37水平。脓毒症组第1天血清IL-37水平[（39.13±34.35）pg/mL]显著高于对照组[（23.75±2.52）pg/mL]，差异有统计学意义（P<0.05）。脓毒症组治疗后第7天IL-37水平[（30.57±11.01）pg/mL]明显低于治疗前，但差异无统计学意义（P>0.05）。相关性分析显示，血清IL-37水平与IL-1β水平呈正相关。脓毒症患者中观察到的IL-37水平与炎症反应的严重程度相关。IL-37可能是通过抑制促炎细胞因子产生来控制脓毒症的重要细胞因子。
