Food Security Research Center, Isfahan University of Medical Sciences , Isfahan , Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences , Isfahan , Iran.
J Am Coll Nutr. 2019 Sep-Oct;38(7):657-658. doi: 10.1080/07315724.2019.1579117. Epub 2019 Mar 11.
We have with great interest read the recent article by Hajihashemi et al. which systematically reviewed and meta-analyzed a number of published clinical trials about the effect of whole grains on serum levels of hs-CRP (high sensitiviy C-reactive protein), IL-6 (interlukin-6), TNF-α (tumor necrosis factor-α). The findings suggested that consumption of whole grains significantly decreased serum levels of hs-CRP and IL-6, but not TNF-α, compared with the control group. It is an interesting study, but there are some methodological limitations and missing data that need to be addressed. Therefore, we believe that the conclusions were misleading and further comprehensive meta-analysis is required to explain the effect of whole grain intake on serum concentrations of inflammatory biomarkers.
我们饶有兴趣地阅读了 Hajihashemi 等人最近的文章，该文系统地回顾和荟萃分析了许多关于全谷物对 hs-CRP（高敏 C 反应蛋白）、IL-6（白细胞介素-6）、TNF-α（肿瘤坏死因子-α）血清水平影响的已发表临床试验。研究结果表明，与对照组相比，全谷物的摄入可显著降低 hs-CRP 和 IL-6 的血清水平，但对 TNF-α 没有影响。这是一项有趣的研究，但存在一些方法学上的局限性和缺失数据，需要解决。因此，我们认为该结论具有误导性，需要进一步进行全面的荟萃分析，以解释全谷物摄入对炎症生物标志物血清浓度的影响。
