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[交感 - 肾上腺系统和激肽释放酶 - 激肽系统在急性实验性主动脉末端闭塞时调节中心血流动力学中的作用]

[Role of the sympathetic-adrenal and kallikrein-kinin systems in regulating central hemodynamics in acute experimental occlusion of the terminal portion of the aorta].

作者信息

Usvatova I Ia, Istomin N P, Chirkova L D, Makarova L D, Mikhelashvili A E

出版信息

Kardiologiia. 1978 Aug;18(8):89-95.

PMID:308571
Abstract

The role of the sympatheticoadrenal and kallikrein-kinin systems in the pathogenesis of hemodynamic disorders was studied in 29 dogs with acute experimental occlusion of the terminal part of the aorta. Data confirming the close dependence of the indices of central hemodynamics on the activity of the sympatheticoadrenal and kallikrein-kinin systems are presented. Close positive correlative connection between activation of the sympatheticoadrenal and kallikrein-kinin systems was revealed. The possible mechanisms of the correction of hemodynamic disorders in severe degree of ischemia by means of agents blocking the kallikrein system are discussed.

摘要

在29只急性实验性主动脉末端闭塞的犬中,研究了交感肾上腺系统和激肽释放酶-激肽系统在血流动力学紊乱发病机制中的作用。提供了证实中心血流动力学指标与交感肾上腺系统和激肽释放酶-激肽系统活性密切相关的数据。揭示了交感肾上腺系统和激肽释放酶-激肽系统激活之间紧密的正相关联系。讨论了通过阻断激肽释放酶系统的药物纠正严重缺血程度血流动力学紊乱的可能机制。

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