半乳糖凝集素-3 对于 A549 肺上皮细胞诱导人嗜碱性粒细胞 IgE 依赖性激活是必需的。
Galectin-3 is essential for IgE-dependent activation of human basophils by A549 lung epithelial cells.
机构信息
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Md.
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Md.
出版信息
J Allergy Clin Immunol. 2019 Jul;144(1):312-315.e1. doi: 10.1016/j.jaci.2019.03.001. Epub 2019 Mar 9.
Abstract
Using novel co-culture model systems, galectin-3 is shown to facilitate basophil secretion of IL-4/IL-13, with implications that this unique mode of activation may be linked to a variety of diseases ranging from asthma to cancer.
摘要
使用新型共培养模型系统表明，半乳糖凝集素-3 可促进嗜碱性粒细胞分泌 IL-4/IL-13，这意味着这种独特的激活方式可能与从哮喘到癌症等各种疾病有关。
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