大戟属华美Euphorbia pulcherrima 的三萜类化合物具有抑制破骨细胞生成的作用。
Triterpenoids from Euphorbia pulcherrima with inhibitory effects on osteoclastogenesis.
机构信息
Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510006, People's Republic of China.
出版信息
Fitoterapia. 2019 Apr;134:355-361. doi: 10.1016/j.fitote.2019.02.028. Epub 2019 Mar 8.
Three new compounds (1-3), euphorimaoid A (1), euphorimaoid B (2), 1α-hydroxy-3β-acetoxy-olean-9,12-diene (3), two firstly isolated natural products 3β-acetyloxy-olean-13(18)-en-12-one (4) and 18,19-epoxyolean-3β-ol acetate (5), together with 13 known compounds (6-18) have been identified from the aerial parts of Euphorbia pulcherrima Willd. Structures of compounds 1-5 were elucidated by comprehensive spectroscopic analysis. The absolute configuration of euphorimaoid A (1) was established using single crystal X-ray diffraction analysis. All the isolates were evaluated for their inhibition of osteoclastogenesis in BMMs. Among them, compounds 7 and 10 showed significantly inhibition in a concentration-dependent manner.
从美丽泽覃大戟的地上部分分离得到三个新化合物（1-3）， euphorimaoid A（1）， euphorimaoid B（2），1α-羟基-3β-乙酰氧基-齐墩烷-9,12-二烯（3），两个首次分离得到的天然产物 3β-乙酰氧基-齐墩烷-13（18）-烯-12-酮（4）和 18,19-环氧齐墩烷-3β-醇乙酸酯（5），以及 13 个已知化合物（6-18）。通过综合光谱分析鉴定了化合物 1-5 的结构。通过单晶 X 射线衍射分析确定了 euphorimaoid A（1）的绝对构型。所有分离得到的化合物都评估了其对破骨细胞分化的抑制作用。其中，化合物 7 和 10 表现出明显的浓度依赖性抑制作用。
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