Nursing School of Shaoyang University, Hunan, China.
Department of Pediatric, Shaoyang Central Hospital, Hunan, China.
Int Wound J. 2023 Jan;20(1):55-62. doi: 10.1111/iwj.13836. Epub 2022 May 14.
A meta-analysis was performed to evaluate the association between vitamin D deficiency and diabetic foot ulcer wounds in diabetic subjects. A systematic literature search up to March 2022 incorporated 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non-ulcerated diabetic subjects. Statistical tools like the dichotomous and contentious method were used within a random or fixed-influence model to establish the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of vitamin D deficiency in managing diabetic foot ulcer wound. Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels (MD, -6.48; 95% CI, -10.84 to -2.11, P < .004), higher prevalence of vitamin D deficiency (<50 nmoL/L) (OR, 1.82; 95% CI, 1.32-2.52, P < .001), and higher prevalence of severe vitamin D deficiency (OR, 2.53; 95% CI, 1.65-3.89, P < .001) compared with non-ulcerated diabetic subjects. Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels, higher prevalence of vitamin D deficiency, and higher prevalence of severe vitamin D deficiency compared with non-ulcerated diabetic subjects. Further studies are required to validate these findings.
一项荟萃分析评估了维生素 D 缺乏与糖尿病患者足部溃疡伤口之间的关联。系统文献检索截至 2022 年 3 月，纳入了研究开始时患有糖尿病的 7586 名受试者；其中 1565 名受试者患有足部溃疡伤口，6021 名受试者未发生溃疡的糖尿病患者。使用二项和争议性方法等统计工具，在随机或固定影响模型内建立比值比（OR）和均数差值（MD），置信区间（CI）为 95%，以评估维生素 D 缺乏对管理糖尿病足溃疡伤口的影响。患有足部溃疡伤口的糖尿病患者的维生素 D 水平明显较低（MD，-6.48；95%CI，-10.84 至-2.11，P < 0.004），维生素 D 缺乏症的患病率更高（<50 nmol/L）（OR，1.82；95%CI，1.32-2.52，P < 0.001），严重维生素 D 缺乏症的患病率更高（OR，2.53；95%CI，1.65-3.89，P < 0.001）与未发生溃疡的糖尿病患者相比。患有足部溃疡伤口的糖尿病患者的维生素 D 水平明显较低，维生素 D 缺乏症的患病率较高，严重维生素 D 缺乏症的患病率较高。需要进一步的研究来验证这些发现。
