Wroński Jakub, Bonek Krzysztof, Stanisławska-Biernat Ewa
Clinic and Polyclinic of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Reumatologia. 2019;57(1):55-58. doi: 10.5114/reum.2019.83241. Epub 2019 Feb 28.
Various silicon compounds have been reported to stimulate autoimmune reactions in the human body. Based on case reports, a possible causal association between silicone breast implants and systemic sclerosis has been suggested since the end of the 1970s. Although the relationship between systemic sclerosis and silicone breast implants has been intensely investigated, no clear evidence of such an association has ever been found in epidemiological studies. Instead, it is now proposed that silicone breast implants can induce nonspecific symptoms of inflammatory diseases, despite not fulfilling the diagnostic criteria for a specific autoimmune disease. This phenomenon was named autoimmune syndrome induced by adjuvants (ASIA syndrome). ASIA syndrome is worth considering in the differential diagnosis in rheumatology patients. In this paper, we present a case of the scleroderma-like syndrome in a 48-year-old woman with a broken silicone breast implant and a review the current literature on this issue.
据报道，多种硅化合物可刺激人体的自身免疫反应。自20世纪70年代末以来，根据病例报告，有人提出硅凝胶乳房植入物与系统性硬化症之间可能存在因果关联。尽管对系统性硬化症与硅凝胶乳房植入物之间的关系进行了深入研究，但在流行病学研究中从未发现这种关联的明确证据。相反，现在有人提出，硅凝胶乳房植入物可诱发炎症性疾病的非特异性症状，尽管不符合特定自身免疫性疾病的诊断标准。这种现象被称为佐剂诱导的自身免疫综合征（ASIA综合征）。ASIA综合征在风湿病患者的鉴别诊断中值得考虑。在本文中，我们报告了一例48岁硅凝胶乳房植入物破裂女性的硬皮病样综合征病例，并综述了关于这一问题的当前文献。
