Albala B J, Moshé S L, Cubells J F, Sharpless N S, Makman M H
Brain Res. 1986 Apr 9;370(2):388-92. doi: 10.1016/0006-8993(86)90500-7.
Recent evidence suggests that the substantia nigra (SN) may be involved in the modulation of kindled seizures in adult rats. In this report we investigated the role of the dopaminergic nigrostriatal pathway in mediating the SN effect on seizures by lesioning this pathway with unilateral infusions of 6-hydroxydopamine (6-OHDA) in the vicinity of the right SN with or without desmethylimipramine pretreatment. Our data suggest that the facilitation of amygdala kindling observed following 6-OHDA lesion in the vicinity of the ipsilateral SN is due to norepinephrine depletion of the ipsilateral forebrain. Selective destruction of the nigrostriatal dopaminergic neurons neither facilitates nor inhibits the development of amygdala-kindled convulsions in adult rats.
最近有证据表明，黑质（SN）可能参与成年大鼠点燃性癫痫发作的调节。在本报告中，我们通过在右侧黑质附近单侧注射6-羟基多巴胺（6-OHDA）损毁多巴胺能黑质纹状体通路，研究了该通路在介导黑质对癫痫发作影响中的作用，注射时有无去甲丙咪嗪预处理。我们的数据表明，同侧黑质附近6-OHDA损伤后观察到的杏仁核点燃促进作用是由于同侧前脑去甲肾上腺素耗竭所致。黑质纹状体多巴胺能神经元的选择性破坏既不促进也不抑制成年大鼠杏仁核点燃性惊厥的发展。
