Morimoto K, Goddard G V
Epilepsia. 1987 Jan-Feb;28(1):1-10. doi: 10.1111/j.1528-1157.1987.tb03613.x.
To investigate the role of the substantia nigra (SN) in kindling, electrical stimulation of the SN was delivered at various times before or after stimulation of the amygdala (AM) or pyriform cortex during or after kindling in rats. The results were as follows: Ipsilateral SN stimulation delivered prior to each AM kindling stimulation for 14 days significantly retarded the appearance of Stage 4 and 5 seizures and shortened the afterdischarge (AD) duration. Bilateral SN prestimulation blocked seizure generalization in some AM- or pyriform cortex-kindled animals, prolonged the latency to bilateral forelimb clonus in others, and shortened the AD duration of the kindled seizure in a current intensity-dependent fashion. These effects were only partially antagonized by haloperidol, but were completely abolished by picrotoxin. The picrotoxin alone significantly reduced the latency. Almost no effect was found when the SN stimulation was delivered after the onset of bilateral forelimb clonus. We conclude that the SN might be an important mediator of the early aspects of seizure generalization from limbic epileptic foci. The relative involvements of GABAergic gamma-aminobutyric acid and dopaminergic systems of the SN in this inhibitory function are discussed.
为研究黑质（SN）在点燃效应中的作用，在大鼠点燃过程中或点燃后，于杏仁核（AM）或梨状皮质刺激之前或之后的不同时间对SN进行电刺激。结果如下：在每次AM点燃刺激前对同侧SN进行14天刺激，可显著延迟4期和5期癫痫发作的出现，并缩短放电后（AD）持续时间。双侧SN预刺激在一些由AM或梨状皮质点燃的动物中可阻断癫痫发作的泛化，在其他动物中可延长双侧前肢阵挛的潜伏期，并以电流强度依赖的方式缩短点燃癫痫发作的AD持续时间。这些效应仅部分被氟哌啶醇拮抗，但被印防己毒素完全消除。单独使用印防己毒素可显著缩短潜伏期。在双侧前肢阵挛发作开始后进行SN刺激时几乎未发现效果。我们得出结论，SN可能是边缘性癫痫病灶癫痫发作泛化早期阶段的重要介导者。文中讨论了SN的γ-氨基丁酸能和多巴胺能系统在这种抑制功能中的相对参与情况。
