Hagood James S
Division of Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Front Cell Dev Biol. 2019 Feb 25;7:26. doi: 10.3389/fcell.2019.00026. eCollection 2019.
Thy-1 was discovered over 50 years ago, and in that time investigators from a broad variety of fields have described numerous and heterogeneous biological functions of Thy-1 in multiple contexts. As an outwardly facing cell surface molecule, it is well positioned to receive extracellular signals; previously reviewed studies have confirmed an important role in cell-cell and cell-matrix adhesion, cell migration, and regulation of outside-in signaling. More recent studies reviewed here expand the repertoire of Thy-1 effects on signaling pathways, and reveal novel roles in mechanotransduction, cellular differentiation, viral entry, and extracellular vesicle binding and internalization. All of these studies contribute to understanding Thy-1 as a context-dependent integrator of a diverse range of extracellular information, and provide impetus for further studies, some of which are suggested here.
Thy-1于50多年前被发现，在那段时间里，来自各个领域的研究人员在多种情况下描述了Thy-1众多且异质性的生物学功能。作为一种面向细胞外的细胞表面分子，它很适合接收细胞外信号；之前的综述研究已经证实了它在细胞间和细胞与基质黏附、细胞迁移以及外向内信号传导调节中发挥重要作用。本文综述的最新研究扩展了Thy-1对信号通路的影响范围，并揭示了其在机械转导、细胞分化、病毒进入以及细胞外囊泡结合与内化中的新作用。所有这些研究都有助于将Thy-1理解为多种细胞外信息的上下文依赖性整合者，并为进一步研究提供了动力，本文提出了其中一些研究建议。
