Wang Ning
School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China; Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
J Phys D Appl Phys. 2017 Jun 14;50(23). doi: 10.1088/1361-6463/aa6e18. Epub 2017 May 17.
Living cells and tissues experience physical forces and chemical stimuli in a human body. The process of converting mechanical forces into biochemical activities and gene expression is mechanochemical transduction or mechanotransduction. Significant advances have been made in understanding mechanotransduction at cellular and molecular levels over the last two decades. However, major challenges remain in elucidating how a living cell integrates signals from mechanotransduction with chemical signals to regulate gene expression and to generate coherent biological responses in living tissues in physiological conditions and diseases.
活细胞和组织在人体中会经历物理力和化学刺激。将机械力转化为生化活动和基因表达的过程称为机械化学转导或机械转导。在过去二十年里，我们对细胞和分子水平上的机械转导的理解取得了重大进展。然而，在阐明活细胞如何将机械转导信号与化学信号整合起来，以在生理条件和疾病状态下调节基因表达并在活组织中产生协调的生物学反应方面，仍然存在重大挑战。
