Wang Qian, Ye Feng, Ma Peiqing, Chen Feng, Che Yiqun, Zhao Xinming, Yang Li
1 Department of Radiology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China.
2 Department of Imaging Diagnosis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Int Med Res. 2019 May;47(5):1958-1974. doi: 10.1177/0300060519836033. Epub 2019 Mar 12.
To explore noninvasive assessment of liver fat content with iron deposition using magnetic resonance (MR) quantitative technology.
A water-fat phantom with iron deposition containing 63 vials with predetermined fat percentages and iron concentrations was constructed. Thirty-three patients underwent fat quantitative MR examinations. The fat fraction (FF) was determined by three Dixon techniques. Pathological evaluation findings and the steatosis area rate (SAR) were used as the gold standards.
FF and FF significantly differed from FF for iron concentrations of 1 to 30 µg/mL and fat components of 10% to 80%. Using the three Dixon techniques, FF was 15.76% ± 6.98%, FF was 16.71% ± 6.77%, and FF was 13.18% ± 6.42% in patients without liver cirrhosis; these values in patients with liver cirrhosis were 20.35% ± 6.11%, 20.89% ± 8.49%, and 12.86% ± 4.00%, respectively. The SAR in patients without and with liver cirrhosis was 11.31% ± 5.89% and 9.84% ± 4.17%, respectively. There were significant positive correlations between FF and SAR with or without liver cirrhosis.
Iron deposition must be considered when using quantitative MR techniques to evaluate the hepatic fat content. Compared with the IOP and LAVA-Flex techniques, the IDEAL IQ technique has more stability and accuracy in measurement of the hepatic fat content, free from iron deposition.
利用磁共振（MR）定量技术探索对伴有铁沉积的肝脏脂肪含量进行无创评估。
构建一个含63个小瓶的、具有预定脂肪百分比和铁浓度的含铁血水脂模体。33例患者接受了脂肪定量MR检查。采用三种狄克逊技术测定脂肪分数（FF）。病理评估结果和脂肪变性面积率（SAR）用作金标准。
对于铁浓度为1至30μg/mL且脂肪成分含量为10%至80%的情况，FF与FF存在显著差异。采用三种狄克逊技术，无肝硬化患者的FF为15.76%±6.98%，FF为16.71%±6.77%，FF为13.18%±6.42%；肝硬化患者的这些值分别为20.35%±6.11%、20.89%±8.49%和12.86%±4.00%。无肝硬化和有肝硬化患者的SAR分别为11.31%±5.89%和9.84%±4.17%。无论有无肝硬化，FF与SAR之间均存在显著正相关。
使用定量MR技术评估肝脏脂肪含量时必须考虑铁沉积。与IOP和LAVA - Flex技术相比，IDEAL IQ技术在测量肝脏脂肪含量方面具有更高的稳定性和准确性，不受铁沉积影响。
