Department of Dermatology, Venereology and Leprology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
Indian J Dermatol Venereol Leprol. 2019 May-Jun;85(3):347. doi: 10.4103/ijdvl.IJDVL_1101_16.
Globally, 36.7 million people are infected with Human Immunodeficiency Virus (HIV). Of these 36.7 million people, 2.1 million are in India. Integrated counseling and testing centers are the cornerstones of early access to prevention and support services. The term "serodiscordant couple" refers to a couple where one partner is HIV-positive and the other HIV-negative.
To study the serodiscordance rates in a cohort of people attending integrated counseling and testing center.
Aretrospective descriptive study of data from integrated counseling and testing center from January 2013 to December 2014 was done.
Of the 7489 persons tested, 306 persons were positive for HIV (192 males and 114 females) with a prevalence of 4 percent. Of the 126 couples tested, serodiscordance was found in 46 couples, while 80 couples were seroconcordant. The overall prevalence of HIV serodiscordance was 36.5 percent. Male positive and female negative couples (M+ F-) were 35 (76.0%) and female positive and male negative (F+ M-) were 11 (23.9%). Discordant M+ F- couples were significantly higher than discordant F+ M- couples (P < 0.001). Most participants were aged between 21 and 40 years. The average age of men was 41.91 years and that of women was 34.21 years. The average age difference between life partners was 7.7 years. Significant association was seen between age and gender, as females were found to be younger (P value = 0.001).
Information regarding years of married life, number of sex partners or sexual behavior pre- and post-detection were not collected. Thus, our data present only the magnitude of serodiscordance in a cohort but does not analyze the other predictors of serodiscordance.
Serodiscordant relationships occur more commonly in India than is presumed. Our study highlights the profile of serodiscordant couples in this part of the country. Effective measures to prevent transmission of HIV within a serodiscordant relationship are necessary steps in halting the HIV epidemic.
全球有 3670 万人感染人类免疫缺陷病毒（HIV）。其中，210 万人在印度。综合咨询和检测中心是早期获得预防和支持服务的基石。“血清不一致的夫妇”一词是指一方为 HIV 阳性而另一方为 HIV 阴性的夫妇。
研究参加综合咨询和检测中心的人群中的血清不一致率。
对 2013 年 1 月至 2014 年 12 月综合咨询和检测中心的数据进行回顾性描述性研究。
在 7489 名受检者中，有 306 人 HIV 阳性（192 名男性和 114 名女性），阳性率为 4%。在 126 对夫妇中，发现血清不一致的有 46 对，而血清一致的有 80 对。总的 HIV 血清不一致率为 36.5%。男性阳性而女性阴性（M+F-）的夫妇有 35 对（76.0%），女性阳性而男性阴性（F+M-）的夫妇有 11 对（23.9%）。不一致的 M+F-夫妇明显高于不一致的 F+M-夫妇（P<0.001）。大多数参与者年龄在 21 至 40 岁之间。男性的平均年龄为 41.91 岁，女性的平均年龄为 34.21 岁。生活伴侣之间的平均年龄差为 7.7 岁。年龄与性别之间存在显著关联，女性年龄较小（P 值=0.001）。
未收集有关已婚年限、性伴侣数量或检测前后的性行为信息。因此，我们的数据仅呈现了一个队列中的血清不一致的程度，但并未分析血清不一致的其他预测因素。
血清不一致的关系在印度比想象中更为常见。我们的研究突出了该国这一地区血清不一致夫妇的特征。采取有效措施防止血清不一致的性关系中的 HIV 传播是阻止 HIV 流行的必要步骤。
