在沙特阿拉伯塔布克使用基因型MTBDR检测多重耐药性。
Detection of multidrug resistant in Tabuk, Saudi Arabia, using Genotype MTBDR.
作者信息
Ahmed-Abakur Eltayib Hassan, Saad Alnour Tarig Mohammed
机构信息
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Tabuk University, Tabuk, Saudi Arabia; Department of Medical Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Al Zaiem Al Azhari University, Khartoum, Sudan.
出版信息
Int J Mycobacteriol. 2019 Jan-Mar;8(1):25-28. doi: 10.4103/ijmy.ijmy_29_19.
BACKGROUND
The global increase in the rates of multidrug-resistant (MDR) tuberculosis (TB) has made the timely identification of resistant Mycobacterium tuberculosis complex strains an important emergence to achieve effective disease management and to prevent their spread in the community. The present study aimed to determine the MDR-TB in Tabuk province, north of the Kingdom of Saudi Arabia.
METHODS
The GenoType MTBDRplus assay was used to determine the mutations associated with isoniazid (INH) and rifampicin (RIF) resistances. A total number of 61 confirmed M. tuberculosis positive-sputum samples were scanned for the mutation in the rpoB, inhA, and katG genes.
RESULTS
The present study revealed that 67.2% of the samples were susceptible, 29.5% were monoresistant, and 3.3% were MDR.
CONCLUSIONS
The monoresistant showed 26.2% for INH and 3.3% for RIF. The early detection of MDR could guide the starting of appropriate regimen of treatment.
背景
耐多药（MDR）结核病（TB）全球发病率上升，及时鉴定结核分枝杆菌复合群耐药菌株对于实现有效的疾病管理以及防止其在社区传播至关重要。本研究旨在确定沙特阿拉伯王国北部塔布克省的耐多药结核病情况。
方法
采用GenoType MTBDRplus检测法确定与异烟肼（INH）和利福平（RIF）耐药相关的突变。对总共61份确诊的结核分枝杆菌阳性痰标本进行rpoB、inhA和katG基因的突变检测。
结果
本研究显示，67.2%的样本敏感，29.5%为单耐药，3.3%为耐多药。
结论
单耐药中，INH为26.2%，RIF为3.3%。耐多药的早期检测可为启动适当的治疗方案提供指导。
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