Loyola-Leyva Alejandra, Loyola-Rodríguez Juan Pablo, Terán Figueroa Yolanda, González Francisco Javier, Atzori Marco, Barquera Cervera Simón
School of Medicine, Autonomous University of San Luis Potosí (Universidad Autónoma de San Luis Potosí), Avenida Venustiano Carranza 2405, Los Filtros, 78210, San Luis Potosí, S.L.P, Mexico.
Laboratory of Nanobiotechnology, Faculty of Medicine, Autonomous University of Guerrero (Universidad Autónoma de Guerrero), Acapulco, Guerrero, Mexico.
Microscopy (Oxf). 2019 Jun 1;68(3):261-270. doi: 10.1093/jmicro/dfz011.
To evaluate the erythrocyte morphology in people with prediabetes, T2DM and healthy subjects in a Mexican population and its association with biochemical parameters.
Cross-sectional study consisted of three groups: healthy (HG), people with prediabetes (PG) and with T2DM (DMG). A blood sample was obtained from all participants to assess the erythrocyte morphology, and levels of HbA1c, glucose and lipid profile. Anthropometrical parameters were also evaluated.
It was observed that compared with healthy individuals, people with prediabetes presented a significant decrease in the diameter (-0.08 μm, P = 0.014) and height (-0.07 μm, P = 0.004), as well as people with T2DM (-0.33 μm, P < 0.001 in diameter; and -0.36 μm, P < 0.001 in height). Besides, it was found a significant difference in diameter (-0.25 μm, P < 0.001) and height (-0.29 μm, P < 0.001) between the PG and DMG. No significant differences in the axial ratio between groups. Also, HbA1c, glucose, triglycerides, cholesterol, LDL cholesterol, systolic blood pressure, weight, BMI, waist and hip circumference were significantly associated with diameter and height.
Erythrocyte morphological alterations can serve as an indicator of early diagnosis of T2DM and a factor implicated in the course of the clinical condition, so the correction of these alterations could serve as a treatment for prediabetes and T2DM. It is essential to promote constantly checkups of biochemical and anthropometrical parameters, as well as erythrocyte morphological alterations to prevent the onset of prediabetes and T2DM and possible clinical complications.
评估墨西哥人群中糖尿病前期患者、2型糖尿病患者及健康受试者的红细胞形态及其与生化参数的关联。
横断面研究包括三组：健康组（HG）、糖尿病前期患者组（PG）和2型糖尿病患者组（DMG）。采集所有参与者的血样以评估红细胞形态、糖化血红蛋白、血糖和血脂水平。还评估了人体测量参数。
观察到，与健康个体相比，糖尿病前期患者的红细胞直径（-0.08μm，P = 0.014）和高度（-0.07μm，P = 0.004）显著减小，2型糖尿病患者也是如此（直径-0.33μm，P < 0.001；高度-0.36μm，P < 0.001）。此外，PG组和DMG组之间的直径（-0.25μm，P < 0.001）和高度（-0.29μm，P < 0.001）存在显著差异。各组之间的轴比无显著差异。此外，糖化血红蛋白、血糖、甘油三酯、胆固醇、低密度脂蛋白胆固醇、收缩压、体重、体重指数、腰围和臀围与直径和高度显著相关。
红细胞形态改变可作为2型糖尿病早期诊断的指标及临床病情发展过程中的一个相关因素，因此纠正这些改变可作为糖尿病前期和2型糖尿病的一种治疗方法。持续促进生化和人体测量参数以及红细胞形态改变的检查对于预防糖尿病前期和2型糖尿病的发生及可能的临床并发症至关重要。
