Infectious Disease Epidemiology Group, Weill Cornell Medicine, Doha, PO Box 24144, Qatar.
Research Faculty, Weill Cornell Medicine, Doha, PO Box 24144, Qatar.
Sci Rep. 2018 Feb 26;8(1):3619. doi: 10.1038/s41598-018-21987-6.
Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM) but its association with prediabetes and T2DM is unknown in Qatar. A cross sectional analysis of 3,017 Qatari subjects from the Qatar Biobank, identified 749 women aged 18-40 years, 720 of whom were assessed by the National Institute for Health (NIH) Guidelines for PCOS. Prediabetes (HbA1c 5.7-6.4% and/or impaired fasting glucose (IFG): fasting plasma glucose (FPG) 100-125 mg/dL (5.6-6.9 mmol/L)), and T2DM (fasting plasma glucose > 125 mg/dL (≥7 mmol/L), and/or HbA1c ≥ 6.5%) were determined. The prevalence of prediabetes was 10.6% and the prevalence of undiagnosed diabetes was found to be 4.0% in the total population. Overall, 12.1% of 720 women had PCOS, of whom FPG and HbA1c were available in 62 women with PCOS: 19.4% had prediabetes and 9.7% had diabetes. An adverse cardiovascular risk profile for IFG women compared to normal women was found. Women with PCOS alone had a similar adverse cardiovascular profile as those with IFG alone and T2DM. Thus, the risk of prediabetes and diabetes is increased in Qatari women with PCOS, with an adverse cardiovascular risk profile similar to that seen in prediabetes and T2DM.
多囊卵巢综合征（PCOS）与 2 型糖尿病（T2DM）的风险增加有关，但在卡塔尔，其与糖尿病前期和 T2DM 的关系尚不清楚。对卡塔尔生物库的 3017 名卡塔尔受试者进行的横断面分析中，确定了 749 名年龄在 18-40 岁的女性，其中 720 名女性接受了国家卫生研究院（NIH）多囊卵巢综合征指南的评估。糖尿病前期（HbA1c5.7-6.4%和/或空腹血糖受损（IFG）：空腹血糖（FPG）100-125mg/dL（5.6-6.9mmol/L））和 T2DM（FPG>125mg/dL（≥7mmol/L）和/或 HbA1c≥6.5%）。总人群中糖尿病前期的患病率为 10.6%，未确诊糖尿病的患病率为 4.0%。总体而言，720 名女性中有 12.1%患有 PCOS，其中 62 名患有 PCOS 的女性有 FPG 和 HbA1c：19.4%患有糖尿病前期，9.7%患有糖尿病。与正常女性相比，IFG 女性的心血管不良风险特征。单独患有 PCOS 的女性与单独患有 IFG 和 T2DM 的女性具有相似的不良心血管特征。因此，患有 PCOS 的卡塔尔女性发生糖尿病前期和糖尿病的风险增加，其心血管不良风险特征与糖尿病前期和 T2DM 相似。
