Kirvelä O K, Takala J A
Eur Surg Res. 1986;18(2):80-5. doi: 10.1159/000128509.
The effects of ketone bodies and glucose on nitrogen balance and liver protein synthesis were studied in rat after experimental trauma. Energy was delivered intravenously as either monoglyceryl acetoacetate (MA; 87.5% of total energy input) or glucose (G). The isocaloric infusions (132 kcal/kg/day) were started after recovery from anaesthesia and continued for 2 days. The liver protein synthesis was then measured in vitro by perfusion with 14C-leucine. The infusion of MA resulted in a more negative cumulative nitrogen balance (MA: -2.31 +/- 0.26 g N/kg, G: -1.32 +/- 0.43 g N/kg/48 h; mean +/- SD) and liver protein synthesis (MA: 43.4 +/- 17.2, G: 71.1 +/- 15.2; arbitrary units, mean +/- SD). The results indicate no benefits from MA during the immediate post-traumatic period.
在实验性创伤后的大鼠中，研究了酮体和葡萄糖对氮平衡及肝脏蛋白质合成的影响。能量通过静脉输注单乙酰甘油乙酸酯（MA；占总能量输入的87.5%）或葡萄糖（G）来提供。等热量输注（132千卡/千克/天）在麻醉恢复后开始，并持续2天。然后通过用14C-亮氨酸灌注在体外测量肝脏蛋白质合成。输注MA导致更负的累积氮平衡（MA：-2.31±0.26克氮/千克，G：-1.32±0.43克氮/千克/48小时；平均值±标准差）和肝脏蛋白质合成（MA：43.4±17.2，G：71.1±15.2；任意单位，平均值±标准差）。结果表明在创伤后即刻阶段，MA没有益处。
