糖尿病会改变药物代谢——链脲佐菌素诱导的糖尿病大鼠模型的体内研究。
Diabetes alters drug metabolism--in vivo studies in a streptozotozin-diabetic rat model.
作者信息
Zysset T, Sommer L
出版信息
Experientia. 1986 May 15;42(5):560-2. doi: 10.1007/BF01946703.
PMID:3086116
Abstract
The influence of experimental streptozotozin-induced diabetes on hepatic drug metabolism in vivo has been studied in rats, using 14CO2-exhalation after 14C-aminopyrine injection. Male diabetic rats showed a decreased (-18%), females an increased (+19%) 14CO2-exhalation compared to controls, indicating altered hepatic drug metabolism due to diabetes.
摘要
利用注射14C-氨基比林后的14CO2呼出法，在大鼠体内研究了实验性链脲佐菌素诱导的糖尿病对肝脏药物代谢的影响。与对照组相比，雄性糖尿病大鼠的14CO2呼出量减少了（-18%），雌性则增加了（+19%），这表明糖尿病导致肝脏药物代谢发生了改变。
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